AMP-activated protein kinase as a drug target

被引：343
作者：
Hardie, D. Grahame [1 ]
机构：
[1] Univ Dundee, Div Mol Physiol, Dundee DD1 5EH, Scotland
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2007年 / 47卷
基金：
英国惠康基金;
关键词：
metformin; biguanides; thiazolidinediones; obesity; diabetes;
D O I：
10.1146/annurev.pharmtox.47.120505.105304
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The AMP-activated protein kinase (AMPK) system is a regulator of energy balance at both the cellular and whole-body levels that, once activated by low energy status, effects a switch from ATP-consuming anabolic pathways to ATP-producing catabolic pathways. It now appears to be the major target for two existing classes of drug used to treat type 2 diabetes, i.e., the biguanides and thiazolidinediones. However, in both cases these activate AMPK indirectly, and an interesting question concerns whether a drug that directly activated AMPK would retain the therapeutic benefits of the existing drugs while eliminating unwanted side effects. AMPK activators also now have potential as anticancer drugs.
引用
收藏
页码：185 / 210
页数：26
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