Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C-F bonds

被引：24

作者：

Cao, Dawei ^{[1
]}

Pan, Pan ^{[1
]}

Zeng, Huiying ^{[1
]}

Li, Chao-Jun ^{[2
,3
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, 222 Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China

[2] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada

[3] McGill Univ, FQRNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 63期

关键词：

CARBON-FLUORINE BONDS; CATALYTIC HYDRODEFLUORINATION; ARYL FLUORIDES; FACILE ACCESS; SELECTIVE DEFLUORINATION; PERFLUORINATED ARENES; N-TOSYLHYDRAZONES; NICKEL; SUBSTITUTION; COMPLEXES;

D O I：

10.1039/c9cc04299g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An umpolung strategy for the cross-coupling of polyfluoroarenes with various substituted hydrazones to construct C(sp(2))-C(sp(3)) bonds is developed. In this strategy, the C-F bond of polyfluoroarenes is cleaved and coupled with moisture- and air-stable hydrazones under mild conditions with good to excellent yields. This method provides a useful tool for synthesizing polyfluorinated pharmaceuticals and functional materials.

引用

收藏

页码：9323 / 9326

页数：4

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