Autophagy in cancer metastasis

被引:373
|
作者
Mowers, E. E. [1 ,2 ]
Sharifi, M. N. [1 ,3 ,4 ]
Macleod, K. F. [1 ,4 ]
机构
[1] Univ Chicago, Ben May Dept Canc Res, 929 East 57th St GCIS W338, Chicago, IL 60422 USA
[2] Univ Chicago, Interdisciplinary Scientist Training Program, Chicago, IL 60637 USA
[3] Univ Chicago, Med Scientist Training Program, Chicago, IL USA
[4] Univ Chicago, Comm Canc Biol, Chicago, IL 60637 USA
关键词
EPITHELIAL-MESENCHYMAL TRANSITION; FOCAL ADHESION KINASE; HYPOXIA-INDUCED AUTOPHAGY; SUPPRESSOR GENE ARHI; BREAST-CANCER; EXTRACELLULAR-MATRIX; STEM-CELLS; OVARIAN-CANCER; TUMOR-CELLS; BONE-MARROW;
D O I
10.1038/onc.2016.333
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autophagy is a highly conserved self-degradative process that has a key role in cellular stress responses and survival. Recent work has begun to explore the function of autophagy in cancer metastasis, which is of particular interest given the dearth of effective therapeutic options for metastatic disease. Autophagy is induced upon progression of various human cancers to metastasis and together with data from genetically engineered mice and experimental metastasis models, a role for autophagy at nearly every phase of the metastatic cascade has been identified. Specifically, autophagy has been shown to be involved in modulating tumor cell motility and invasion, cancer stem cell viability and differentiation, resistance to anoikis, epithelial-to-mesenchymal transition, tumor cell dormancy and escape from immune surveillance, with emerging functions in establishing the pre-metastatic niche and other aspects of metastasis. In this review, we provide a general overview of how autophagy modulates cancer metastasis and discuss the significance of new findings for disease management.
引用
收藏
页码:1619 / 1630
页数:12
相关论文
共 50 条
  • [21] Autophagy and Tumour Metastasis
    Hou, Jing
    Han, Zhipeng
    Zhao, Naping
    Wei, Lixin
    AUTOPHAGY: BIOLOGY AND DISEASES: CLINICAL SCIENCE, 2020, 1207 : 315 - 338
  • [22] Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy
    M Gugnoni
    V Sancisi
    G Gandolfi
    G Manzotti
    M Ragazzi
    D Giordano
    I Tamagnini
    M Tigano
    A Frasoldati
    S Piana
    A Ciarrocchi
    Oncogene, 2017, 36 : 667 - 677
  • [23] Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis (Review)
    Xu, Yinghua
    Xia, Xiaoping
    Pan, Hongming
    ONCOLOGY LETTERS, 2013, 5 (02) : 411 - 416
  • [24] Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance
    Wang, Xin
    Lee, Jihye
    Xie, Changqing
    CANCERS, 2022, 14 (02)
  • [25] Autophagy suppresses breast cancer metastasis by degrading NBR1
    Marsh, Timothy
    Debnath, Jayanta
    AUTOPHAGY, 2020, 16 (06) : 1164 - 1165
  • [26] Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy
    Gugnoni, M.
    Sancisi, V.
    Gandolfi, G.
    Manzotti, G.
    Ragazzi, M.
    Giordano, D.
    Tamagnini, I.
    Tigano, M.
    Frasoldati, A.
    Piana, S.
    Ciarrocchi, A.
    ONCOGENE, 2017, 36 (05) : 667 - 677
  • [27] EMT, cancer stem cells and autophagy; The three main axes of metastasis
    Babaei, Ghader
    Aziz, Shiva Gholizadeh-Ghaleh
    Jaghi, Nasrin Zare Zavieyh
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 133
  • [28] The role of FOXOs and autophagy in cancer and metastasis-Implications in therapeutic development
    Farhan, Mohd
    Silva, Marta
    Li, Shuai
    Yan, Fengxia
    Fang, Jiankang
    Peng, Tangming
    Hu, Jim
    Tsao, Ming-Sound
    Little, Peter
    Zheng, Wenhua
    MEDICINAL RESEARCH REVIEWS, 2020, 40 (06) : 2089 - 2113
  • [29] The pleiotropic functions of autophagy in metastasis
    Marsh, Timothy
    Tolani, Bhairavi
    Debnath, Jayanta
    JOURNAL OF CELL SCIENCE, 2021, 134 (02)
  • [30] Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells
    Qin, Wenjie
    Li, Chao
    Zheng, Wen
    Guo, Qingqu
    Zhang, Yuefeng
    Kang, Muxing
    Zhang, Bo
    Yang, Bin
    Li, Baozhong
    Yang, Haijun
    Wu, Yulian
    ONCOTARGET, 2015, 6 (37) : 39839 - 39854