Does the progesterone receptor genetic polymorphism+331G/A hPR influence the risk of venous thromboembolism among postmenopausal women using hormone therapy? The ESTHER Study

被引：1

作者：

Bouaziz, Elodie ^{[3
]}

Canonico, Marianne ^{[1
,2
]}

Verstuyft, Celine ^{[3
,4
]}

Carcaillon, Laure ^{[1
,2
]}

Martin, Frederic ^{[3
]}

Scarabin, Pierre-Yves ^{[1
,2
]}

Guiochon-Mantel, Anne ^{[3
,5
,6
]}

机构：

[1] Univ Paris Sud, INSERM, Cardiovasc Sect, U780, F-94807 Villejuif, France

[2] Univ Paris Sud, IFR69, F-94807 Villejuif, France

[3] Univ Paris Sud, Hop Bicetre, AP HP, Lab Genet Mol Pharmacogenet & Hormonol, F-94275 Le Kremlin Bicetre, France

[4] Univ Paris Sud, Fac Med, Dept Pharmacol, F-94275 Le Kremlin Bicetre, France

[5] Univ Paris Sud, INSERM, U693, F-94275 Le Kremlin Bicetre, France

[6] Univ Paris Sud, IFR93, F-94275 Le Kremlin Bicetre, France

来源：

MATURITAS | 2009年 / 64卷 / 02期

关键词：

Progesterone receptor; Venous thromboembolism; Hormone therapy; EXPRESSION;

D O I：

10.1016/j.maturitas.2009.08.013

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Hormone therapy (HT) increases venous thromboembolism (VTE) risk among postmenopausal women. Data on the influence of steroids receptors polymorphisms on this association remain scarce. Since progesterone receptor (hPR) is expressed in human veins and specific progestogens increase WE risk, we investigated the impact of the functional +331G/A hPR polymorphism on the association of WE with HT. Using the data of the ESTHER study, we showed that ORs for WE in current users of progesterone or progestins were not significantly different by hPR +331G/A genotype status. hPR polymorphism appears not to have a significant effect on WE risk related to HT. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：136 / 138

页数：3

共 5 条

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