Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells

被引：16

作者：

Masumi, Atsuko ^{[1
]}

Hamaguchi, Isao ^{[1
]}

Kuramitsu, Madoka ^{[1
]}

Mizukami, Takuo ^{[1
]}

Takizawa, Kazuya ^{[1
]}

Momose, Haruka ^{[1
]}

Naito, Seishiro ^{[1
]}

Yamaguchi, Kazunari ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Safety Res Blood & Biol Prod, Tokyo, Japan

来源：

FEBS LETTERS | 2009年 / 583卷 / 21期

基金：

日本学术振兴会;

关键词：

IRF-2; Stem cell; Inflammation; Megakaryopoiesis; Gene regulation; DIAMOND-BLACKFAN-ANEMIA; RIBOSOMAL-PROTEIN S19; STEM-CELLS; TRANSCRIPTION FACTOR; GENE-EXPRESSION; IRF FAMILY; PROMOTER; PROGENITORS; DIFFERENTIATION; GATA-1;

D O I：

10.1016/j.febslet.2009.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Megakaryopoiesis is associated with in. ammatory reactions. To investigate the role of interferon regulatory factors (IRFs) in inflammation-associated megakaryopoiesis, mouse bone marrow hematopoietic stem cells (HSCs) were analyzed. IFN-gamma treatment induced IRF-2 expression as well as the expression of CD41 and IRF-1 in HSCs. An in vitro clonogenic assay showed that IRF-2- but not IRF-1-overexpressing cells increased the number of megakaryocytic colonies. IRF-2 transfection up-regulated CD41 promoter activity in hematopoietic cell lines. The number of CD41-positive bone marrow cells increased in mice injected with IRF-2-expressing bone marrow cells. These findings suggest that IRF-2 plays an important role in megakaryopoiesis in in. ammatory states. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3493 / 3500

页数：8

共 33 条

[1] PLATELET GLYCOPROTEIN IIB GENE-EXPRESSION AS A MODEL OF MEGAKARYOCYTE-SPECIFIC EXPRESSION [J].

BLOCK, KL ;

PONCZ, M .

STEM CELLS, 1995, 13 (02) :135-145

[2] The IFN regulatory factor family participates in regulation of Fas ligand gene expression in T cells [J].

Chow, WA ;

Fang, JJ ;

Yee, JK .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3512-3518

[3] Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells [J].

de la Grange, Philippe Brunet ;

Armstrong, Florence ;

Duval, Veronique ;

Rouyez, Marie-Christine ;

Goardon, Nicolas ;

Romeo, Paul-Henri ;

Pflumio, Francoise .

BLOOD, 2006, 108 (09) :2998-3004

[4] Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia [J].

Flygare, J ;

Kiefer, T ;

Miyake, K ;

Utsugisawa, T ;

Hamaguchi, I ;

Da Costa, L ;

Richter, J ;

Davey, EJ ;

Matsson, H ;

Dahl, N ;

Wiznerowicz, M ;

Trono, D ;

Karlsson, S .

BLOOD, 2005, 105 (12) :4627-4634

[5] Proliferation deficiency of multipotent hematopoietic progenitors in ribosomal protein S19 (RPS19)-deficient Diamond-Blackfan anemia improves following RPS19 gene transfer [J].

Hamaguchi, I ;

Flygare, J ;

Nishiura, H ;

Brun, ACM ;

Ooka, A ;

Kiefer, T ;

Ma, Z ;

Dah, N ;

Richter, J ;

Karlsson, S .

MOLECULAR THERAPY, 2003, 7 (05) :613-622

[6] STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice [J].

Huang, Zan ;

Richmond, Terri D. ;

Muntean, Andrew G. ;

Barber, Dwayne L. ;

Weiss, Mitchell J. ;

Crispino, John D. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (12) :3890-3899

[7] Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation [J].

Ikonomi, P ;

Rivera, CE ;

Riordan, M ;

Washington, G ;

Schechter, AN ;

Noguchi, CT .

EXPERIMENTAL HEMATOLOGY, 2000, 28 (12) :1423-1431

[8] Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2 [J].

Kitajima, K ;

Tanaka, M ;

Zheng, J ;

Yen, H ;

Sato, A ;

Sugiyama, D ;

Umehara, H ;

Sakai, E ;

Nakano, T .

BLOOD, 2006, 107 (05) :1857-1863

[9] HES-1 preserves, purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo [J].

Kunisato, A ;

Chiba, S ;

Nakagami-Yamaguchi, E ;

Kumano, K ;

Saito, T ;

Masuda, S ;

Yamaguchi, T ;

Osawa, M ;

Kageyama, R ;

Nakauchi, H ;

Nishikawa, M ;

Hirai, H .

BLOOD, 2003, 101 (05) :1777-1783

[10] Deficient RPS19 protein production induces cell cycle arrest in erythroid progenitor cells [J].

Kuramitsu, Madoka ;

Hamaguchi, Isao ;

Takuo, Mizukami ;

Masumi, Atsuko ;

Momose, Haruka ;

Takizawa, Kazuya ;

Mochizuki, Masayo ;

Naito, Seishirou ;

Yamaguchi, Kazunari .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 140 (03) :348-359

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