TLC densitometric determination of mometasone furoate in topical preparations: Validation

A simple and rapid densitometric method has been developed for determination of mometasone furoate in the topical pharmaceutical preparations. After extraction of the analyte with 96% ethanol, the extracts were spotted on pre-coated silica gel plates, which were then developed with a mixture of dichloromethane-diethyl ether (3 : 1). Quantitative evaluation was performed by measuring the absorbance reflectance of the analyte spots at 260 nm. The densitometric method is selective, precise, and accurate and can be used for routine analysis of the topical preparations in pharmaceutical industry quality control laboratories.