Isoxazoles from 1,1-disubstituted bromoalkenes

被引：58

作者：

Dadiboyena, Sureshbabu ^{[1
]}

Xu, Jianping ^{[1
]}

Hamme, Ashton T., II ^{[1
]}

机构：

[1] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 07期

关键词：

cycloaddition; regioselectivity; heterocycles; alkyne surrogate; dehydrohalogenation;

D O I：

10.1016/j.tetlet.2006.12.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective synthesis of 3,5-disubstituted isoxazoles was achieved through the 1,3-dipolar cycloaddition of nitrile oxides with 1,1-disubstituted bromoalkenes. The substituted bromoalkenes function as alkyne synthons which were used to construct 5,5-disubstituted bromoisoxazoline intermediates that aromatize to the analogous isoxazoles through the loss of HBr. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1295 / 1298

页数：4

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