Molecular genotyping of hepatitis B virus

被引：0
作者：
Clarke, B [1 ]
Bloor, S [1 ]
机构：
[1] Visible Genet Inc, Cambridge CB4 0GA, England
来源：
JOURNAL OF CLINICAL VIROLOGY | 2002年 / 25卷
关键词：
hepatitis B virus; chronic infection; therapy; lamivudine; resistance; genotyping;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The development of new therapeutic agents against hepatitis B virus (HBV) and the predictable emergence of resistant mutants have highlighted the need to provide new molecular assays for optimal therapeutic management. Similarly, other variants and genotypes of HBV have now been identified that appear to have distinct clinical and pathological. importance. This paper outlines the current clinical importance of HBV on a global scale, reviews the current generation of molecular genotyping assays and discusses the prospects for new assays in the near future. (C) 2002 Elsevier Science B.V. All rights reserved.
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收藏
页码：S41 / S45
页数：5
相关论文
共 23 条
[1]   Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine [J].
Allen, MI ;
Gauthier, J ;
DesLauriers, M ;
Bourne, EJ ;
Carrick, KM ;
Baldanti, F ;
Ross, LL ;
Lutz, MW ;
Condreay, LD .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (10) :3338-3347
[2]   VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS [J].
CARMAN, WF ;
ZANETTI, AR ;
KARAYIANNIS, P ;
WATERS, J ;
MANZILLO, G ;
TANZI, E ;
ZUCKERMAN, AJ ;
THOMAS, HC .
LANCET, 1990, 336 (8711) :325-329
[3]   Lamivudine as initial treatment for chronic hepatitis B in the United States [J].
Dienstag, JL ;
Schiff, ER ;
Wright, TL ;
Perrillo, RP ;
Hann, HWL ;
Goodman, Z ;
Crowther, L ;
Condreay, LD ;
Woessner, M ;
Rubin, M ;
Brown, NA .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (17) :1256-1263
[4]  
Fujie H, 2001, GASTROENTEROLOGY, V120, P1564, DOI 10.1053/gast.2001.24501
[5]   World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants [J].
Funk, ML ;
Rosenberg, DM ;
Lok, ASF .
JOURNAL OF VIRAL HEPATITIS, 2002, 9 (01) :52-61
[6]  
GERMER JJ, IN PRESS J HEPATOL
[7]   Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers [J].
Hou, JL ;
Wang, ZH ;
Cheng, JJ ;
Lin, YL ;
Lau, GKK ;
Sun, J ;
Zhou, FY ;
Waters, J ;
Karayiannis, P ;
Luo, KX .
HEPATOLOGY, 2001, 34 (05) :1027-1034
[8]   Characterization of two hepatitis B virus populations isolated from a hepatitis B surface antigen-negative patient [J].
Jeantet, D ;
Chemin, I ;
Mandrand, B ;
Zoulim, F ;
Trepo, C ;
Kay, A .
HEPATOLOGY, 2002, 35 (05) :1215-1224
[9]   Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B [J].
Kao, JH ;
Chen, PJ ;
Lai, MY ;
Chen, DS .
GASTROENTEROLOGY, 2000, 118 (03) :554-559
[10]   Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy [J].
Leung, NWY ;
Lai, CL ;
Chang, TT ;
Guan, R ;
Lee, CM ;
Ng, KY ;
Lim, SG ;
Wu, PC ;
Dent, JC ;
Edmundson, S ;
Condreay, LD ;
Chien, RN .
HEPATOLOGY, 2001, 33 (06) :1527-1532
123