Insular resting state functional connectivity is associated with gut microbiota diversity

被引:38
作者
Curtis, Kaylah [1 ,2 ]
Stewart, Christopher J. [3 ]
Robinson, Meghan [4 ]
Molfese, David L. [1 ,2 ]
Gosnell, Savannah N. [1 ,2 ,5 ]
Kosten, Thomas R. [1 ,2 ,5 ]
Petrosino, Joseph F. [3 ]
De La Garza, Richard, II [1 ,2 ,5 ]
Sales, Ramiro [1 ,2 ,5 ]
机构
[1] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, One Baylor Plaza,A277, Houston, TX 77030 USA
[2] Michael E DeBakey VA Med Ctr, Houston, TX USA
[3] Baylor Coll Med, Alkek Ctr Metagen & Microbiome Res, Dept Mol Virol & Microbiol, Houston, TX 77025 USA
[4] Baylor Coll Med, Dept Neurosurg, Houston, TX 77025 USA
[5] Baylor Coll Med, Dept Neurosci, Houston, TX 77025 USA
关键词
electronic cigarette; fMRI; insula; microbiome; tobacco; BRAIN; DEPENDENCE; DYSBIOSIS; ALTERS;
D O I
10.1111/ejn.14305
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The gut microbiota has recently gained attention as a possible modulator of brain activity. A number of reports suggest that the microbiota may be associated with neuropsychiatric conditions such as major depressive disorder, autism and anxiety. The gut microbiota is thought to influence the brain via vagus nerve signalling, among other possible mechanisms. The insula processes and integrates these vagal signals. To determine if microbiota diversity and structure modulate brain activity, we collected faecal samples and examined insular function using resting state functional connectivity (RSFC). Thirty healthy participants (non-smokers, tobacco smokers and electronic cigarette users, n = 10 each) were studied. We found that the RSFC between the insula and several regions (frontal pole left, lateral occipital cortex right, lingual gyrus right and cerebellum 4, 5 and vermis 9) were associated with bacterial microbiota diversity and structure. In addition, two specific bacteria genera, Prevotella and Bacteroides, were specifically different in tobacco smokers and also associated with insular connectivity. In conclusion, we show that insular connectivity is associated with microbiome diversity, structure and at least two specific bateria genera. Furthemore, this association is potentially modulated by tobacco smoking, although the sample sizes for the different smoking groups were small and this result needs validation in a larger cohort. While replication is necessary, the microbiota is a readily accessible therapeutic target for modulating insular connectivity, which has previously been shown to be abnormal in anxiety and tobacco use disorders.
引用
收藏
页码:2446 / 2452
页数:7
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