共 131 条
Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse
被引:59
作者:

Hammer, John A.
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机构:
NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA

Wang, Jia C.
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h-index: 0
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NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA

Saeed, Mezida
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h-index: 0
机构:
NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA

Pedrosa, Antonio T.
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h-index: 0
机构:
NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA
机构:
[1] NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA
来源:
ANNUAL REVIEW OF IMMUNOLOGY, VOL 37, 2019
|
2019年
/
37卷
关键词:
T cell;
actin;
myosin;
immunological synapse;
lytic granule;
formin;
ALDRICH-SYNDROME PROTEIN;
LYTIC GRANULE SECRETION;
F-ACTIN;
FAMILY PROTEINS;
RECEPTOR MICROCLUSTERS;
RETROGRADE FLOW;
ADAPTER PROTEIN;
ARP2/3;
COMPLEX;
ACTIVATION;
CYTOSKELETON;
D O I:
10.1146/annurev-immunol-042718-041341
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy.
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页码:201 / 224
页数:24
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共 131 条
[1]
Cellular functions of WASP family proteins at a glance
[J].
Alekhina, Olga
;
Burstein, Ezra
;
Billadeau, Daniel D.
.
JOURNAL OF CELL SCIENCE,
2017, 130 (14)
:2235-2241

Alekhina, Olga
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med, Div Oncol Res, Rochester, MN 55905 USA Mayo Clin, Coll Med, Div Oncol Res, Rochester, MN 55905 USA

Burstein, Ezra
论文数: 0 引用数: 0
h-index: 0
机构:
UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
UT Southwestern Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Mayo Clin, Coll Med, Div Oncol Res, Rochester, MN 55905 USA

Billadeau, Daniel D.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med, Div Oncol Res, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA Mayo Clin, Coll Med, Div Oncol Res, Rochester, MN 55905 USA
[2]
Live-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse
[J].
Ashdown, George W.
;
Burn, Garth L.
;
Williamson, David J.
;
Pandzic, Elvis
;
Peters, Ruby
;
Holden, Michael
;
Ewers, Helge
;
Shao, Lin
;
Wiseman, Paul W.
;
Owen, Dylan M.
.
BIOPHYSICAL JOURNAL,
2017, 112 (08)
:1703-1713

Ashdown, George W.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Dept Phys, London, England
Kings Coll London, Randall Div Cell & Mol Biophys, London, England Kings Coll London, Dept Phys, London, England

Burn, Garth L.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Dept Phys, London, England
Kings Coll London, Randall Div Cell & Mol Biophys, London, England
Max Planck Inst Infect Biol, Berlin, Germany Kings Coll London, Dept Phys, London, England

Williamson, David J.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Dept Phys, London, England
Kings Coll London, Randall Div Cell & Mol Biophys, London, England Kings Coll London, Dept Phys, London, England

Pandzic, Elvis
论文数: 0 引用数: 0
h-index: 0
机构:
Univ New South Wales, Mark Wainwright Analyt Ctr, Sydney, NSW, Australia Kings Coll London, Dept Phys, London, England

Peters, Ruby
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Dept Phys, London, England
Kings Coll London, Randall Div Cell & Mol Biophys, London, England Kings Coll London, Dept Phys, London, England

Holden, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Dept Phys, London, England
Kings Coll London, Randall Div Cell & Mol Biophys, London, England Kings Coll London, Dept Phys, London, England

Ewers, Helge
论文数: 0 引用数: 0
h-index: 0
机构:
Free Univ Berlin, Inst Chem & Biochem, Berlin, Germany Kings Coll London, Dept Phys, London, England

Shao, Lin
论文数: 0 引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Adv Imaging Ctr, Janelia Res Campus, Ashburn, VA USA Kings Coll London, Dept Phys, London, England

Wiseman, Paul W.
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Dept Chem, Montreal, PQ, Canada
McGill Univ, Dept Phys, Montreal, PQ, Canada Kings Coll London, Dept Phys, London, England

Owen, Dylan M.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Dept Phys, London, England
Kings Coll London, Randall Div Cell & Mol Biophys, London, England Kings Coll London, Dept Phys, London, England
[3]
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation
[J].
Babich, Alexander
;
Li, Shuixing
;
O'Connor, Roddy S.
;
Milone, Michael C.
;
Freedman, Bruce D.
;
Burkhardt, Janis K.
.
JOURNAL OF CELL BIOLOGY,
2012, 197 (06)
:775-787

Babich, Alexander
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Li, Shuixing
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

O'Connor, Roddy S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Milone, Michael C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Freedman, Bruce D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathobiol, Sch Vet Med, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Burkhardt, Janis K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[4]
Mechanical Communication at the Immunological Synapse
[J].
Basu, Roshni
;
Huse, Morgan
.
TRENDS IN CELL BIOLOGY,
2017, 27 (04)
:241-254

Basu, Roshni
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA

Huse, Morgan
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA
[5]
Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing
[J].
Basu, Roshni
;
Whitlock, Benjamin M.
;
Husson, Julien
;
Le Floc'h, Audrey
;
Jin, Weiyang
;
Oyler-Yaniv, Alon
;
Dotiwala, Farokh
;
Giannone, Gregory
;
Hivroz, Claire
;
Biais, Nicolas
;
Lieberman, Judy
;
Kam, Lance C.
;
Huse, Morgan
.
CELL,
2016, 165 (01)
:100-110

Basu, Roshni
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Whitlock, Benjamin M.
论文数: 0 引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Biochem & Mol Biol Grad Program, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Husson, Julien
论文数: 0 引用数: 0
h-index: 0
机构:
Ecole Polytech, Hydrodynam Lab LadHyX, Dept Mech, F-91128 Palaiseau, France Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Le Floc'h, Audrey
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Jin, Weiyang
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Oyler-Yaniv, Alon
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Dotiwala, Farokh
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Program Cellular & Mol Med, Sch Med, Boston, MA 02115 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Giannone, Gregory
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bordeaux, Interdisciplinary Inst Neurosci, UMR 5297, CNRS, F-33000 Bordeaux, France Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Hivroz, Claire
论文数: 0 引用数: 0
h-index: 0
机构:
PSL Res Univ, INSERM, U932, Inst Curie, F-75005 Paris, France Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Biais, Nicolas
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Brooklyn Coll, Dept Biol, New York, NY 11201 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Lieberman, Judy
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Program Cellular & Mol Med, Sch Med, Boston, MA 02115 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Kam, Lance C.
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

Huse, Morgan
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA
[6]
Myosin II isoform co-assembly and differential regulation in mammalian systems
[J].
Beach, Jordan R.
;
Hammer, John A., III
.
EXPERIMENTAL CELL RESEARCH,
2015, 334 (01)
:2-9

Beach, Jordan R.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA

Hammer, John A., III
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA
[7]
An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse
[J].
Bertrand, Florie
;
Mueller, Sabina
;
Roh, Kyung-Ho
;
Laurent, Camille
;
Dupre, Loic
;
Valitutti, Salvatore
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2013, 110 (15)
:6073-6078

Bertrand, Florie
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France
Univ Toulouse 3, F-31062 Toulouse, France
Lab Excellence Toulouse Canc, Toulouse, France Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France

Mueller, Sabina
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France
Univ Toulouse 3, F-31062 Toulouse, France
Lab Excellence Toulouse Canc, Toulouse, France Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France

Roh, Kyung-Ho
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France

Laurent, Camille
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France
Univ Toulouse 3, F-31062 Toulouse, France
Lab Excellence Toulouse Canc, Toulouse, France Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France

Dupre, Loic
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France
Univ Toulouse 3, F-31062 Toulouse, France
Lab Excellence Toulouse Canc, Toulouse, France Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France

Valitutti, Salvatore
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France
Univ Toulouse 3, F-31062 Toulouse, France
Lab Excellence Toulouse Canc, Toulouse, France Ctr Physiopathol Toulouse Purpan, INSERM, Unite Mixte Rech 1043, Sect Dynam Mol Interact Lymphocytaires, F-31024 Toulouse, France
[8]
Regulation of T-cell activation by the cytoskeleton
[J].
Billadeau, Daniel D.
;
Nolz, Jeffrey C.
;
Gomez, Timothy S.
.
NATURE REVIEWS IMMUNOLOGY,
2007, 7 (02)
:131-143

Billadeau, Daniel D.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Nolz, Jeffrey C.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Gomez, Timothy S.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA
[9]
Formins at a glance
[J].
Breitsprecher, Dennis
;
Goode, Bruce L.
.
JOURNAL OF CELL SCIENCE,
2013, 126 (01)
:1-7

Breitsprecher, Dennis
论文数: 0 引用数: 0
h-index: 0
机构:
Brandeis Univ, Dept Biol, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02454 USA Brandeis Univ, Dept Biol, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02454 USA

Goode, Bruce L.
论文数: 0 引用数: 0
h-index: 0
机构:
Brandeis Univ, Dept Biol, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02454 USA Brandeis Univ, Dept Biol, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02454 USA
[10]
Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy
[J].
Brown, Alice C. N.
;
Oddos, Stephane
;
Dobbie, Ian M.
;
Alakoskela, Juha-Matti
;
Parton, Richard M.
;
Eissmann, Philipp
;
Neil, Mark A. A.
;
Dunsby, Christopher
;
French, Paul M. W.
;
Davis, Ilan
;
Davis, Daniel M.
.
PLOS BIOLOGY,
2011, 9 (09)

Brown, Alice C. N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Oddos, Stephane
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Dobbie, Ian M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Biochem, Oxford OX1 3QU, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Alakoskela, Juha-Matti
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Parton, Richard M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Biochem, Oxford OX1 3QU, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Eissmann, Philipp
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Neil, Mark A. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Phys, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Dunsby, Christopher
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Phys, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

French, Paul M. W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Phys, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Davis, Ilan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Biochem, Oxford OX1 3QU, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

Davis, Daniel M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England