Atrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications

被引：58

作者：

Linz, Dominik ^{[1
]}

Linz, Benedikt ^{[1
]}

Hohl, Mathias ^{[1
]}

Boehm, Michael ^{[1
]}

机构：

[1] Univ Klinikum Saarlandes, Kardiol Angiol & Internist Intens Med, Saarlandes, Germany

来源：

SLEEP MEDICINE REVIEWS | 2016年 / 26卷

关键词：

Atrial fibrillation; Obstructive sleep apnea; Continuous positive airway pressure; Renal denervation; Atrial electrophysiology; Animal experiment; POSITIVE AIRWAY PRESSURE; RENIN-ANGIOTENSIN SYSTEM; BLOOD-PRESSURE; PULMONARY VEIN; RENAL DENERVATION; HEART-FAILURE; CARDIOVASCULAR-RESPONSES; FIBRILLATION RECURRENCE; RESPIRATORY EVENTS; MUELLER MANEUVER;

D O I：

10.1016/j.smrv.2015.03.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The prevalence of sleep disordered breathing like obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF) is 40-50%. OSA reduces success rate of catheter based and pharmacological antiarrhythmic treatment. Additionally, efficient treatment of OSA by continuous positive airway pressure ventilation (CPAP), the first line therapy of OSA, has been shown to improve catheter ablation success rates in AF-patients. A systematic literature search using several databases was performed to review the pathophysiology of obstructive apneas in OSA potentially leading to the development of a substrate for AF and to explain potential mechanisms involved in the clinically observed atrial antiarrhythmic effect of effective CPAP therapy. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：87 / 94

页数：8

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