Preparation of 166Dy/166Ho-chitosan as an in vivo generator for radiosynovectomy

被引：5
作者：
Vosoughi, Sara [1 ]
Jalilian, Amir R. [1 ]
Shirvani-Arani, Simindokht [1 ]
Bahrami-Samani, Ali [1 ]
Salek, Nafiseh [1 ]
机构：
[1] NSTRI, POB 14155-1339, Tehran, Iran
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2017年 / 311卷 / 03期
关键词：
Dy-166; Ho-166; In vivo generator; Extraction chromatography; Radiosynovectomy; Radiopharmaceutical; QUALITY-CONTROL; SYSTEM;
D O I：
10.1007/s10967-016-5146-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Ho-166 is one of the most effective radionuclides used for radiosynovectomy. One method to deliver this radioisotope to target tissue is via the Dy-166/Ho-166 in vivo generator system. The aim of this work was to prepare Dy-166/Ho-166-chitosan (Dy-166/Ho-166-CHIT) in vivo generator for radiosynovectomy applications. Dy-166 obtained by the irradiation of natural Dy-164 target. Dy-166 was separated from Ho-166 by extraction chromatographic method (separation yield; 93% and separation factor; 1.7). Chitosan labeling was performed in acetic acid with 99.3 +/- 0.6% radiochemical purity. Biodistribution studies on intraarticular injected rats demonstrated high retention in the knee joint even 7 days showing no radioactivity leakage from the injection site into other organs as well as any translocation of the daughter nucleus after beta(-) decay of Dy-166.
引用
收藏
页码：1657 / 1664
页数：8
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