The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

被引：231

作者：

Cicala, Claudia ^{[1
]}

Martinelli, Elena ^{[1
]}

McNally, Jonathan P. ^{[1
]}

Goode, Diana J. ^{[1
]}

Gopaul, Ravindra ^{[1
]}

Hiatt, Joseph ^{[1
]}

Jelicic, Katija ^{[1
]}

Kottilil, Shyamasundaran ^{[1
]}

Macleod, Katilyn ^{[1
]}

O'Shea, Angeline ^{[1
]}

Patel, Nikita ^{[1
]}

Van Ryk, Donald ^{[1
]}

Wei, Danlan ^{[1
]}

Pascuccio, Massimiliano ^{[1
]}

Yi, Ling ^{[2
]}

McKinnon, Lyle ^{[3
]}

Izulla, Preson ^{[4
]}

Kimani, Joshua ^{[4
]}

Kaul, Rupert ^{[3
]}

Fauci, Anthony S. ^{[1
]}

Arthos, James ^{[1
]}

机构：

[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

[3] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada

[4] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 49期

基金：

美国国家卫生研究院;

关键词：

integrin receptor; transmission; gut-associated lymphoid tissues (GALT); MUCOSAL HOMING RECEPTOR; RETINOIC ACID; DEPLETION; ALPHA-4-BETA-7; TRANSMISSION; LYMPHOCYTES; ROLES; LFA-1; SIV;

D O I：

10.1073/pnas.0911796106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin alpha(4)beta(7) (alpha(4)beta(7)), the gut mucosal homing receptor. We find that alpha(4)beta(high)(7) CD4(+) T cells are more susceptible to productive infection than are alpha(4)beta(low-neg)(7) CD4(+) T cells in part because this cellular subset is enriched with metabolically active CD4(+) T cells. alpha(4)beta(high)(7) CD4(+) T cells are CCR5(high) and CXCR4(low); on these cells, alpha(4)beta(7) appears in a complex with CD4. The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.

引用

页码：20877 / 20882

页数：6

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