Wilms tumor genetics: A new, unX-pected twist to the story

被引：8

作者：

Huff, Vicki ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Canc Genet, Houston, TX 77030 USA

来源：

CANCER CELL | 2007年 / 11卷 / 02期

关键词：

D O I：

10.1016/j.ccr.2007.01.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The study of the genetics of Wilms tumor has led to several highly unexpected and precedent-establishing discoveries. Ironically, however, the identification of "WT genes" has been painfully slow, and gene mutations have been identified in only similar to 25% of tumors. The discovery of an X chromosome gene, WTX, that is mutated somatically in similar to 30% of Wilms tumors is notable both for helping to explain the genetic etiology of a substantial proportion of tumors and also for underscoring the role that X chromosome genes can play in cancer genetics.

引用

页码：105 / 107

页数：3

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