Toward an understanding of regulatory T cells in COVID-19: A systematic review

被引：42

作者：

Rahimzadeh, Mahsa ^{[1
,2
]}

Naderi, Nadereh ^{[3
]}

机构：

[1] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Infect & Trop Dis Res Ctr, Bandar Abbas, Iran

[2] Hormozgan Univ Med Sci, Dept Biochem, Fac Med, Bandar Abbas, Iran

[3] Hormozgan Univ Med Sci, Dept Immunol, Fac Med, Bandar Abbas, Iran

来源：

JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 07期

关键词：

COVID-19; immune response; regulatory T cell; PERIPHERAL-BLOOD; LYMPHOCYTE SUBSETS; LUNG INJURY; INFECTION; TYPE-1; TH17; DIFFERENTIATION; SUSCEPTIBILITY; INFLAMMATION; AUTOIMMUNE;

D O I：

10.1002/jmv.26891

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A more detailed understanding of Treg cells in COVID-19 infection will broaden our knowledge of the COVID-19 immunopathology and give us more insight into the curative immune-based strategies. We systematically searched electronic databases (PubMed, Google Scholar, EMBASE) and identified 18 eligible studies. Despite the inconsistencies between the results, we observed a trend toward decreasing Treg levels in severe COVID-19 patients. This finding underlines the hypothesis that Tregs play a role in the pathogenesis of COVID-19. Further studies on Tregs' functional aspects are necessary to illustrate Tregs' potential role in COVID-19 disease.

引用

页码：4167 / 4181

页数：15

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