Toward an understanding of regulatory T cells in COVID-19: A systematic review

被引：42
作者：
Rahimzadeh, Mahsa [1 ,2 ]
Naderi, Nadereh [3 ]
机构：
[1] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Infect & Trop Dis Res Ctr, Bandar Abbas, Iran
[2] Hormozgan Univ Med Sci, Dept Biochem, Fac Med, Bandar Abbas, Iran
[3] Hormozgan Univ Med Sci, Dept Immunol, Fac Med, Bandar Abbas, Iran
来源：
JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 07期
关键词：
COVID-19; immune response; regulatory T cell; PERIPHERAL-BLOOD; LYMPHOCYTE SUBSETS; LUNG INJURY; INFECTION; TYPE-1; TH17; DIFFERENTIATION; SUSCEPTIBILITY; INFLAMMATION; AUTOIMMUNE;
D O I：
10.1002/jmv.26891
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A more detailed understanding of Treg cells in COVID-19 infection will broaden our knowledge of the COVID-19 immunopathology and give us more insight into the curative immune-based strategies. We systematically searched electronic databases (PubMed, Google Scholar, EMBASE) and identified 18 eligible studies. Despite the inconsistencies between the results, we observed a trend toward decreasing Treg levels in severe COVID-19 patients. This finding underlines the hypothesis that Tregs play a role in the pathogenesis of COVID-19. Further studies on Tregs' functional aspects are necessary to illustrate Tregs' potential role in COVID-19 disease.
引用
收藏
页码：4167 / 4181
页数：15
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