Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes

被引：19
|
作者：
Suga, Mika [1 ,2 ]
Kondo, Takayuki [1 ,2 ,3 ]
Inoue, Haruhisa [1 ,2 ,3 ]
机构：
[1] RIKEN, BRC, iPSC Based Drug Discovery & Dev Team, Kyoto 6190237, Japan
[2] Kyoto Univ, Ctr iPS Cell Res & Applicat CiRA, Kyoto 6068507, Japan
[3] RIKEN, Ctr Adv Intelligence Project AIP, Med Risk Avoidance Based iPS Cells Team, Kyoto 6068507, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 16期
关键词：
astrocytes; disease modeling; iPSC; induced pluripotent stem cells; glia; human neurological disorders; DIRECTED DIFFERENTIATION; ASTROGLIAL SUBTYPES; NEURAL PROGENITORS; GLIAL-CELLS; REVEALS; DISEASE; PATHOLOGY; TRANSCRIPTOME; SPECIFICATION; PURIFICATION;
D O I：
10.3390/ijms20163862
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Astrocytes play vital roles in neurological disorders. The use of human induced pluripotent stem cell (iPSC)-derived astrocytes provides a chance to explore the contributions of astrocytes in human diseases. Here we review human iPSC-based models for neurological disorders associated with human astrocytes and discuss the points of each model.
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页数：12
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