Retroposed new genes out of the X in Drosophila

被引：353

作者：

Betrán, E

Thornton, K

Long, M

机构：

[1] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[2] Univ Chicago, Comm Genet, Chicago, IL 60637 USA

来源：

GENOME RESEARCH | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1101/gr.6049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New genes that originated by various molecular mechanisms are an essential component in understanding the evolution of genetic systems. We investigated the pattern of origin of the genes created by retroposition in Drosophila. We surveyed the whole Drosophila melanogaster genome for such new retrogenes and experimentally analyzed their functionality and evolutionary process. These retrogenes, functional as revealed by the analysis of expression, substitution, and population genetics, show a surprisingly asymmetric pattern in their origin. There is a significant excess of retrogenes that originate from the X chromosome and retropose to autosomes; new genes retroposed from autosomes are scarce. Further, we found that most of these X-derived autosomal retrogenes had evolved a testis expression pattern. These observations may be explained by natural selection favoring those new retrogenes that moved to autosomes and avoided the spermatogenesis X inactivation, and suggest the important role of genome position for the origin of new genes.

引用

页码：1854 / 1859

页数：6

共 42 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2] Gene discovery using computational and microarray analysis of transcription in the Drosophila melanogaster testis [J].

Andrews, J ;

Bouffard, GG ;

Cheadle, C ;

Lü, JN ;

Becker, KG ;

Oliver, B .

GENOME RESEARCH, 2000, 10 (12) :2030-2043

[3]

[Anonymous], METHOD ENZYMOL

[4]

ASHBURNER M, 1989, DROSPHILA LAB HDB

[5]

Begun DJ, 1997, GENETICS, V145, P375

[6] PREFERENTIAL INSERTION OF P-ELEMENTS INTO GENES EXPRESSED IN THE GERM-LINE OF DROSOPHILA-MELANOGASTER [J].

BOWNES, M .

MOLECULAR & GENERAL GENETICS, 1990, 222 (2-3) :457-460

[7] RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements [J].

Brosius, J .

GENE, 1999, 238 (01) :115-134

[8] RETROPOSONS - SEEDS OF EVOLUTION [J].

BROSIUS, J .

SCIENCE, 1991, 251 (4995) :753-753

[9]

CASTRILLON DH, 1993, GENETICS, V135, P489

[10] THE RELATIVE RATES OF EVOLUTION OF SEX-CHROMOSOMES AND AUTOSOMES [J].

CHARLESWORTH, B ;

COYNE, JA ;

BARTON, NH .

AMERICAN NATURALIST, 1987, 130 (01) :113-146

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