Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi

被引：13

作者：

Xie, Chun-Lan ^{[1
,2
]}

Zhang, Duo ^{[1
]}

Lin, Ting ^{[1
]}

He, Zhi-Hui ^{[2
]}

Yan, Qing-Xiang ^{[2
]}

Cai, Qi ^{[1
]}

Zhang, Xiao-Kun ^{[1
]}

Yang, Xian-Wen ^{[2
]}

Chen, Hai-Feng ^{[1
]}

机构：

[1] Xiamen Univ, Sch Pharmaceut Sci, Xiamen, Peoples R China

[2] Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

deep-sea; fungi; sorbicillinoids; cell cycle; cytotoxicities;

D O I：

10.3389/fmicb.2020.636948

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two new (1-2) and three known (3-5) sorbicillinoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580. Compounds 1 and 2, named sorbicatechols C and D, were two new hybrid dihydrosorbillinoids. Their structures were established mainly by spectroscopic analyses and electronic circular dichroism (ECD) calculations. All five isolates were tested for antiproliferative activities against four tumor cell lines of MCF-7, HT-29, HuH-7, and LNCap. Compounds 2 and 5 inhibited HT-29 cells in a good dose-dependent manner. Mechanism investigation uncovered that they could significantly induce cell cycle G2-M phase arresting by increasing the protein levels of p-H3 and cyclin B1.

引用

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