Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

被引：54

作者：

Trend, Stephanie ^{[1
,2
]}

Leffler, Jonatan ^{[1
]}

Jones, Anderson P. ^{[1
]}

Cha, Lilian ^{[1
]}

Gorman, Shelley ^{[1
]}

Brown, David A. ^{[3
,4
]}

Breit, Samuel N. ^{[5
]}

Kermode, Allan G. ^{[2
,6
]}

French, Martyn A. ^{[7
,8
]}

Ward, Natalie C. ^{[9
,10
]}

Hart, Prue H. ^{[1
]}

机构：

[1] Univ Western Australia, Telethon Kids Inst, POB 855, Perth, WA 6872, Australia

[2] Univ Western Australia, Perron Inst Neurol & Translat Sci, Ctr Neuromuscular & Neurol Disorders, Perth, WA, Australia

[3] Univ Sydney, NSW Hlth Pathol, Inst Clin Pathol & Med Res, Sydney, NSW, Australia

[4] Univ Sydney, Westmead Inst Med Res, Ctr Immunol & Allergy Res, Sydney, NSW, Australia

[5] Univ NSW, St Vincents Hosp, St Vincents Ctr Appl Med Res, Sydney, NSW, Australia

[6] Murdoch Univ, Inst Immunol & Infect Dis, Perth, WA, Australia

[7] Univ Western Australia, UWA Med Sch, Perth, WA, Australia

[8] Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia

[9] Univ Western Australia, Med Sch, Perth, WA, Australia

[10] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Publ Hlth, Perth, WA, Australia

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/s41598-021-84881-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Altered composition of gut bacteria and changes to the production of their bioactive metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of multiple sclerosis (MS). However, the immunomodulatory actions of SCFAs and intermediaries in their ability to influence MS pathogenesis are uncertain. In this study, levels of serum SCFAs were correlated with immune cell abundance and phenotype as well as with other relevant serum factors in blood samples taken at first presentation of Clinically Isolated Syndrome (CIS; an early form of MS) or MS and compared to healthy controls. There was a small but significant reduction in propionate levels in the serum of patients with CIS or MS compared with healthy controls. The frequencies of circulating T follicular regulatory cells and T follicular helper cells were significantly positively correlated with serum levels of propionate. Levels of butyrate associated positively with frequencies of IL-10-producing B-cells and negatively with frequencies of class-switched memory B-cells. TNF production by polyclonally-activated B-cells correlated negatively with acetate levels. Levels of serum SCFAs associated with changes in circulating immune cells and biomarkers implicated in the development of MS.

引用

页数：15

共 57 条

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