TNF receptor-associated factor 1 is a positive regulator of the NF-κB alternative pathway

被引：27

作者：

Lavorgna, Alfonso ^{[1
]}

De Filippi, Rosaria ^{[1
]}

Formisano, Silvestro ^{[1
]}

Leonardi, Antonio ^{[1
]}

机构：

[1] Univ Naples Federico 2, Dipartimento Biol & Patol Cellulare & Mol, I-80131 Naples, Italy

来源：

MOLECULAR IMMUNOLOGY | 2009年 / 46卷 / 16期

关键词：

NF-kappa B; TRAF1; BAFF-R; REED-STERNBERG CELLS; HODGKINS LYMPHOMA; MULTIPLE-MYELOMA; ACTIVATION; TRAF2; KINASE; UBIQUITINATION; TRANSCRIPTION; EXPRESSION; PATIENT;

D O I：

10.1016/j.molimm.2009.07.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor receptor-associated factor 1 (TRAF1) is unique among the members of the TRAF family, as it lacks the N-terminal RING/zinc-finger domain. Also the function of TRAF1 is not clearly established, with many papers reporting contradictory results. Here we show that TRAF1 interacts with BAFF receptor, a member of the TNF receptor family, and positively regulates activation of the alternative NF-kappa B pathway. Ectopic expression of TRAF1 causes degradation of TRAF3, stabilization of NIK, and processing of p100 to produce the mature form p52. In addition, we show that knocking-down expression of TRAF1 in the Hodgkin's disease derived cell line L1236, interfere with p100 processing and with p52 mediate gene transcription. Collectively these results support a role for TRAF1 as a positive regulator of the NF-kappa B alternative pathway. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3278 / 3282

页数：5

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