MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling
被引:18
|
作者:
Zhang, Qingzhu
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机构:
Chengde Med Univ, Dept Orthoped, Affiliated Hosp, Chengde, Peoples R ChinaChengde Med Univ, Dept Orthoped, Affiliated Hosp, Chengde, Peoples R China
Zhang, Qingzhu
[1
]
Yin, Xuelian
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机构:
Chengde Med Univ, Dept Stomatol, Affiliated Hosp, Chengde, Peoples R ChinaChengde Med Univ, Dept Orthoped, Affiliated Hosp, Chengde, Peoples R China
Yin, Xuelian
[2
]
Zhang, Yi
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机构:
Chengde Med Univ, Dept Orthoped Trauma, Affiliated Hosp, Chengde 067000, Hebei, Peoples R ChinaChengde Med Univ, Dept Orthoped, Affiliated Hosp, Chengde, Peoples R China
Zhang, Yi
[3
]
机构:
[1] Chengde Med Univ, Dept Orthoped, Affiliated Hosp, Chengde, Peoples R China
[2] Chengde Med Univ, Dept Stomatol, Affiliated Hosp, Chengde, Peoples R China
[3] Chengde Med Univ, Dept Orthoped Trauma, Affiliated Hosp, Chengde 067000, Hebei, Peoples R China
microRNAs;
miR-221;
FBXW11;
Osteosarcoma cells;
Cancer progression;
D O I:
10.1016/j.arcmed.2020.10.017
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Background and objectives. MicroRNAs play a crucial role in the progression of various cancers, and microRNA-221 (miR-221) has been observed to be significantly overexpressed in osteosarcoma (OS) cells. FBXW11, a vital F-box protein of the ubiquitin-proteasome system, mediates the proliferation and survival of cancer cells by targeting multiple substrates for degradation. FBXW11 inhibits OS growth and metastasis by antagonizing the beta-catenin/Wnt signaling pathway. Therefore, we hypothesized that miR-221 targets FBXW11 to mediate Wnt signaling and promote OS proliferation. Methods. In this study, we demonstrated the increased expression of miR-221 and FBXW11 in OS tissues and cell lines by real-time polymerase chain reaction (RT-PCR). Moreover, to elucidate the regulatory mechanism(s) of miR-221 and FBXW11 in progression, cell viability and apoptosis were analyzed by the MTT assay and flow cytometry, respectively. Results. The results showed that the overexpression of miR-221 in OS cells dramatically promoted cell growth and cell cycle progression, and inhibited apoptosis, whereas miR-221 inhibitors conversely inhibited proliferation and promoted apoptosis in OS cells. The data also showed that FBXW11 directly targeted miR-221 and miR-221 regulated OS cell proliferation and apoptosis by binding to FBXW11. We further confirmed that miR-221 targeted FBXW11 to promote proliferation and inhibit apoptosis in OS cell lines by inhibiting Wnt signaling. Interpretation and conclusions. Overall, our study revealed a functional mechanism for miR-221 in OS. Further studies will elucidate its role in the progression of OS and inhibiting miR-221 may represent a useful treatment strategy. (C) 2021 IMSS. Published by Elsevier Inc.
机构:
Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Affiliated Hosp 2, Dept Orthopaed, Chongqing, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Zhang, Ran-Xi
Li, Yang
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Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Sch Pharm, Dept Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Li, Yang
Tian, Dong-Dong
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机构:
Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Affiliated Hosp 2, Dept Orthopaed, Chongqing, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Tian, Dong-Dong
Liu, Yang
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Chongqing Med Univ, Affiliated Hosp 2, Dept Orthopaed, Chongqing, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Liu, Yang
Nian, Wu
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Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Affiliated Hosp 2, Dept Orthopaed, Chongqing, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Nian, Wu
Zou, Xiang
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Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Affiliated Hosp 2, Dept Orthopaed, Chongqing, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Zou, Xiang
Chen, Qian-Zhao
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Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Sch Pharm, Dept Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chen, Qian-Zhao
Zhou, Lin-Yun
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Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Sch Pharm, Dept Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Zhou, Lin-Yun
Deng, Zhong-Liang
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Chongqing Med Univ, Affiliated Hosp 2, Dept Orthopaed, Chongqing, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Deng, Zhong-Liang
He, Bai-Cheng
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Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
Chongqing Med Univ, Sch Pharm, Dept Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R ChinaChongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
机构:
Jilin Univ, Dept Surg, China Japan Union Hosp, 126 Xiantai Rd, Changchun 130033, Jilin, Peoples R ChinaJilin Univ, Dept Surg, China Japan Union Hosp, 126 Xiantai Rd, Changchun 130033, Jilin, Peoples R China
Zhou, Guanghong
Jiang, Hao
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Jilin Univ, Dept Surg, China Japan Union Hosp, 126 Xiantai Rd, Changchun 130033, Jilin, Peoples R ChinaJilin Univ, Dept Surg, China Japan Union Hosp, 126 Xiantai Rd, Changchun 130033, Jilin, Peoples R China
Jiang, Hao
Ma, Liping
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Jilin Univ, Dept Nursing, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R ChinaJilin Univ, Dept Surg, China Japan Union Hosp, 126 Xiantai Rd, Changchun 130033, Jilin, Peoples R China
机构:
Capital Med Univ, Beijing Rehabil Hosp, Clin Lab, Beijing 100041, Peoples R ChinaCapital Med Univ, Beijing Rehabil Hosp, Clin Lab, Beijing 100041, Peoples R China
Cao, Wei
Fang, Le
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521 Hosp Ordnance Ind, Dept Blood Transfus, Xian 710065, Shaanxi, Peoples R ChinaCapital Med Univ, Beijing Rehabil Hosp, Clin Lab, Beijing 100041, Peoples R China
Fang, Le
Teng, Siyong
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Natl Ctr Cardiovasc Dis, Dept Cardiovasc Med, Beijing 102300, Peoples R ChinaCapital Med Univ, Beijing Rehabil Hosp, Clin Lab, Beijing 100041, Peoples R China
Teng, Siyong
Chen, Hongwei
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Shanghai Songjiang Dist Cent Hosp, Clin Lab, Shanghai 201600, Peoples R ChinaCapital Med Univ, Beijing Rehabil Hosp, Clin Lab, Beijing 100041, Peoples R China
Chen, Hongwei
Liu, Tiejun
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Capital Med Univ, Beijing Rehabil Hosp, Dept Urol, Badachu Rd, Beijing 100144, Peoples R ChinaCapital Med Univ, Beijing Rehabil Hosp, Clin Lab, Beijing 100041, Peoples R China
机构:
Armed Police Corps Hosp, Dept Oncol, Guangzhou 510507, Guangdong, Peoples R China
Jinan Univ, Sch Med, Dept Pathol, Guangzhou, Guangdong, Peoples R ChinaArmed Police Corps Hosp, Dept Oncol, Guangzhou 510507, Guangdong, Peoples R China
Xie, Qiang
Yan, Yongrong
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Jinan Univ, Sch Med, Dept Pathol, Guangzhou, Guangdong, Peoples R ChinaArmed Police Corps Hosp, Dept Oncol, Guangzhou 510507, Guangdong, Peoples R China
Yan, Yongrong
Huang, Zuoping
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Jinan Univ, Sch Med, Dept Pathol, Guangzhou, Guangdong, Peoples R ChinaArmed Police Corps Hosp, Dept Oncol, Guangzhou 510507, Guangdong, Peoples R China
Huang, Zuoping
Zhong, Xueyun
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Jinan Univ, Sch Med, Dept Pathol, Guangzhou, Guangdong, Peoples R ChinaArmed Police Corps Hosp, Dept Oncol, Guangzhou 510507, Guangdong, Peoples R China
Zhong, Xueyun
Huang, Lei
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Armed Police Corps Hosp, Dept Oncol, Guangzhou 510507, Guangdong, Peoples R ChinaArmed Police Corps Hosp, Dept Oncol, Guangzhou 510507, Guangdong, Peoples R China
机构:
Daqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R ChinaDaqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R China
Liu, Zhiqiang
Li, Qiang
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Daqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R ChinaDaqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R China
Li, Qiang
Zhao, Xin
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Daqing Oilfield Gen Hosp, Dept Heart Noninvas Examinat, Daqing, Heilongjiang, Peoples R ChinaDaqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R China
Zhao, Xin
Cui, Bin
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Daqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R ChinaDaqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R China
Cui, Bin
Zhang, Libo
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Daqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R ChinaDaqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R China
Zhang, Libo
Wang, Qiang
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Daqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R ChinaDaqing Long Nan Hosp, Dept Orthoped, Daqing, Heilongjiang, Peoples R China