Atrial fibrillation and migraine with aura in young adults with ischemic stroke

被引：21

作者：

Gollion, Cedric ^{[1
,2
]}

Gazagnes, Julie ^{[1
]}

Fabry, Vincent ^{[1
]}

Barbieux-Guillot, Marianne ^{[1
]}

Lerebours, Fleur ^{[1
]}

Larrue, Vincent ^{[1
]}

机构：

[1] Univ Toulouse, Dept Neurol, Toulouse, France

[2] Univ Toulouse, Toulouse NeuroImaging Ctr, INSERM, ToNIC, Inserm, France

来源：

CEPHALALGIA | 2021年 / 41卷 / 03期

关键词：

Stroke; migraine; ASCOD; atrial fibrillation; PATENT FORAMEN OVALE; CEREBRAL INFARCTION; CRYPTOGENIC STROKE; RISK-FACTORS; AGE;

D O I：

10.1177/0333102420970880

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Migraine is associated with an increased risk of ischemic stroke. The associations are stronger in migraine with aura than in migraine without aura, in women than in men, and in younger subjects. However, the mechanisms by which migraine might increase the risk of ischemic stroke are debated. Methods We analysed the associations between migraine without aura and migraine with aura and the causes of ischemic stroke in patients aged 18-54 years treated consecutively in a university hospital stroke center. Results A total of 339 patients (mean/SD age 43.8/8.8 years, 62.83% male) were included. Migraine with aura was diagnosed in 58 patients, and migraine without aura in 54 patients. Patients with migraine with aura were younger and had fewer traditional cardiovascular risk factors than patients with no migraine. Migraine with aura was strongly associated with atrial fibrillation (odds ratio, 5.08; 95% confidence interval, 1.24-21.92; p = 0.011) and negatively associated with atherosclerosis (odds ratio, 0.29; 95% confidence interval, 0.05-0.97; p = 0.033) and small vessel disease (odds ratio, 0.13; 95% confidence interval, 0.00-0.87; p = 0.022). No other cause of stroke was significantly associated with migraine. The most common cause of stroke was atherosclerosis in no-migraine patients, dissection in migraine without aura patients and patent foramen ovale in migraine with aura patients. Atrial fibrillation was, together with dissection, the second leading cause of stroke in migraine with aura patients, accounting for 10.34% of cases in this subgroup. Conclusion We showed that atrial fibrillation was a common cause of ischemic stroke in young adults with migraine with aura.

引用

页码：375 / 382

页数：8

共 27 条

[11] Risk Factors for Early-Onset Ischemic Stroke: A Case-Control Study [J].

Kivioja, Reetta ;

Pietila, Arto ;

Martinez-Majander, Nicolas ;

Gordin, Daniel ;

Havulinna, Aki S. ;

Salomaa, Veikko ;

Aarnio, Karoliina ;

Curtze, Sami ;

Leiviska, Jaana ;

Rodriguez-Pardo, Jorge ;

Surakka, Ida ;

Kaste, Markku ;

Tatlisumak, Turgut ;

Putaala, Jukka .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018, 7 (21)

[12] Clinical and imaging findings in cryptogenic stroke patients with and without patent foramen ovale - The PFO-ASA study [J].

Lamy, C ;

Giannesini, C ;

Zuber, M ;

Arquizan, C ;

Meder, JF ;

Trystram, D ;

Coste, J ;

Mas, JL .

STROKE, 2002, 33 (03) :706-711

[13] Etiologic investigation of ischemic stroke in young adults [J].

Larrue, V. ;

Berhoune, N. ;

Massabuau, P. ;

Calviere, L. ;

Raposo, N. ;

Viguier, A. ;

Nasr, N. .

NEUROLOGY, 2011, 76 (23) :1983-1988

[14] Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke [J].

Mas, J. -L. ;

Derumeaux, G. ;

Guillon, B. ;

Massardier, E. ;

Hosseini, H. ;

Mechtouff, L. ;

Arquizan, C. ;

Bejot, Y. ;

Vuillier, F. ;

Detante, O. ;

Guidoux, C. ;

Canaple, S. ;

Vaduva, C. ;

Dequatre-Ponchelle, N. ;

Sibon, I. ;

Garnier, P. ;

Ferrier, A. ;

Timsit, S. ;

Robinet-Borgomano, E. ;

Sablot, D. ;

Lacour, J. -C. ;

Zuber, M. ;

Favrole, P. ;

Pinel, J. -F. ;

Apoil, M. ;

Reiner, P. ;

Lefebvre, C. ;

Guerin, P. ;

Piot, C. ;

Rossi, R. ;

Dubois-Rande, J. -L. ;

Eicher, J. -C. ;

Meneveau, N. ;

Lusson, J. -R. ;

Bertrand, B. ;

Schleich, J. -M. ;

Godart, F. ;

Thambo, J. -B. ;

Leborgne, L. ;

Michel, P. ;

Pierard, L. ;

Turc, G. ;

Barthelet, M. ;

Charles-Nelson, A. ;

Weimar, C. ;

Moulin, T. ;

Juliard, J. -M. ;

Chatellier, G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (11) :1011-1021

[15] Migraine in cervical artery dissection and ischemic stroke patients [J].

Metso, T. M. ;

Tatlisumak, T. ;

Debette, S. ;

Dallongeville, J. ;

Engelter, S. T. ;

Lyrer, P. A. ;

Thijs, V. ;

Bersano, A. ;

Abboud, S. ;

Leys, D. ;

Grond-Ginsbach, C. ;

Kloss, M. ;

Touze, E. ;

Pezzini, A. ;

Metso, A. J. .

NEUROLOGY, 2012, 78 (16) :1221-1228

[16] Migraine and Autonomic Dysfunction: Which Is the Horse and Which Is the Jockey? [J].

Miglis, Mitchell G. .

CURRENT PAIN AND HEADACHE REPORTS, 2018, 22 (03)

[17] Etiology of and risk factors for cerebral infarction in young adults in western Norway: a population-based case-control study [J].

Naess, H ;

Nyland, HI ;

Thomassen, L ;

Aarseth, J ;

Myhr, KM .

EUROPEAN JOURNAL OF NEUROLOGY, 2004, 11 (01) :25-30

[18] Microemboli May Link Spreading Depression, Migraine Aura, and Patent Foramen Ovale [J].

Nozari, Ala ;

Dilekoz, Ergin ;

Sukhotinsky, Inna ;

Stein, Thor ;

Eikermann-Haerter, Katharina ;

Liu, Christina ;

Wang, Yumei ;

Frosch, Matthew P. ;

Waeber, Christian ;

Ayata, Cenk ;

Moskowitz, Michael A. .

ANNALS OF NEUROLOGY, 2010, 67 (02) :221-229

[19] Migraine and risk of stroke [J].

Oie, Lise R. ;

Kurth, Tobias ;

Gulati, Sasha ;

Dodick, David W. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2020, 91 (06) :593-604

[20] Predictors of Long-Term Recurrent Vascular Events After Ischemic Stroke at Young Age The Italian Project on Stroke in Young Adults [J].

Pezzini, Alessandro ;

Grassi, Mario ;

Lodigiani, Corrado ;

Patella, Rosalba ;

Gandolfo, Carlo ;

Zini, Andrea ;

DeLodovici, Maria Luisa ;

Paciaroni, Maurizio ;

Del Sette, Massimo ;

Toriello, Antonella ;

Musolino, Rossella ;

Calabro, Rocco Salvatore ;

Bovi, Paolo ;

Adami, Alessandro ;

Silvestrelli, Giorgio ;

Sessa, Maria ;

Cavallini, Anna ;

Marcheselli, Simona ;

Bonifati, Domenico Marco ;

Checcarelli, Nicoletta ;

Tancredi, Lucia ;

Chiti, Alberto ;

Del Zotto, Elisabetta ;

Spalloni, Alessandra ;

Giossi, Alessia ;

Volonghi, Irene ;

Costa, Paolo ;

Giacalone, Giacomo ;

Ferrazzi, Paola ;

Poli, Loris ;

Morotti, Andrea ;

Rasura, Maurizia ;

Simone, Anna Maria ;

Gamba, Massimo ;

Cerrato, Paolo ;

Micieli, Giuseppe ;

Melis, Maurizio ;

Massucco, Davide ;

De Giuli, Valeria ;

Iacoviello, Licia ;

Padovani, Alessandro .

CIRCULATION, 2014, 129 (16) :1668-1676

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