Prognostic roles of Notch receptor mRNA expression in human ovarian cancer

被引：25
作者：
Chen, Chuan [1 ,2 ]
Wang, Xiaojiao [3 ]
Huang, Shunping [4 ]
Wang, Lin [5 ]
Han, Lili [5 ]
Yu, Songtao [3 ]
机构：
[1] Third Mil Med Univ, Daping Hosp, Canc Ctr, Chongqing 400042, Peoples R China
[2] Third Mil Med Univ, Res Inst Surg, Chongqing 400042, Peoples R China
[3] Third Mil Med Univ, Southwest Hosp, Dept Oncol, Chongqing 400038, Peoples R China
[4] Chongqing Med Univ, Dept Oncol, Affiliated Hosp 2, Chongqing 400010, Peoples R China
[5] Peoples Hosp Xinjiang Uyhgur Autonomous Reg, Dept Gynecol, Urumqi 830001, Xinjiang, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 20期
关键词：
Notch receptor; mRNA expression; KM plotter; hazard ratio; prognosis; BREAST-CANCER; GAMMA-SECRETASE; MICROARRAY DATA; DOWN-REGULATION; POOR SURVIVAL; TUMOR-GROWTH; CELLS; MAMMARY; INHIBITION; GENE;
D O I：
10.18632/oncotarget.16387
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aberrant activation of Notch signaling pathway has been correlated with high grade ovarian carcinoma and carcinogenesis. However, the predictive and prognostic values of Notch signaling pathway in ovarian cancer patients remains unclear. We utilize "The Kaplan-Meier plotter" ( KM plotter) background database to access the prognostic values including overall survival ( OS), progression-free survival ( PFS), as well as post-progression survival ( PPS) of four Notch receptor mRNA expression in ovarian cancer patients. Notch1 mRNA high expression was not correlated with OS, PFS and PPS for all ovarian cancer patients, but significantly correlated with poor PFS in TP53 wild type and favorite PFS in TP53 mutation type ovarian cancer patients. Notch2 mRNA high expression was significantly correlated with poor PFS for all ovarian cancer patients, especially in grade II patients. Notch3 mRNA high expression was significantly correlated with favorite PFS for all ovarian cancer patients. Notch4 mRNA high expression was significantly correlated with favorite OS, but not PFS and PPS for all ovarian cancer patients. The results strongly support that there are distinct prognostic values of four Notch receptor mRNA expression in ovarian cancer patients.
引用
收藏
页码：32731 / 32740
页数：10
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