Diffusion tensor imaging of native and degenerated human articular cartilage

被引:77
作者
Deng, Xiang
Farley, Michelle
Nieminen, Miika T.
Gray, Martha
Burstein, Deborah
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02115 USA
[2] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[3] New England Baptist Bone & Joint Inst, Boston, MA 02115 USA
关键词
diffusion tenser imaging; cartilage; degradation; trypsin; collagenase;
D O I
10.1016/j.mri.2006.10.015
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Diffusion tensor imaging (DTI) is potentially sensitive to collagen degeneration in cartilage. In this study, DTI was measured on human cartilage samples with interventions of trypsin and collagenase. The measured preferred diffusion direction was consistent with the zonal structure of collagen network. The glycosaminoglycan concentration decreased and apparent diffusion coefficient increased with both interventions. The fractional anisotropy (FA) was not affected by trypsin and showed a slight increase with combined trypsin and collagenase intervention. DTI in cartilage is technically challenging due to the low FA and the almost undetectable change with collagen disruption seen here. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:168 / 171
页数:4
相关论文
共 18 条
[11]  
Hsu EW, 1999, MAGNET RESON MED, V41, P992, DOI 10.1002/(SICI)1522-2594(199905)41:5<992::AID-MRM19>3.0.CO
[12]  
2-Y
[13]  
Knauss R, 1999, MAGNET RESON MED, V41, P285, DOI 10.1002/(SICI)1522-2594(199902)41:2<285::AID-MRM11>3.0.CO
[14]  
2-3
[15]   Diffusion tensor imaging of in vivo and excised rat spinal cord at 7 T with an icosahedral encoding scheme [J].
Madi, S ;
Hasan, KM ;
Narayana, PA .
MAGNETIC RESONANCE IN MEDICINE, 2005, 53 (01) :118-125
[16]   Diffusion tensor MR imaging of the human brain [J].
Pierpaoli, C ;
Jezzard, P ;
Basser, PJ ;
Barnett, A ;
DiChiro, G .
RADIOLOGY, 1996, 201 (03) :637-648
[17]   Aggrecan protects cartilage collagen from proteolytic cleavage [J].
Pratta, MA ;
Yao, WQ ;
Decicco, C ;
Tortorella, MD ;
Liu, RQ ;
Copeland, RA ;
Magolda, R ;
Newton, RC ;
Trzaskos, JM ;
Arner, EC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) :45539-45545
[18]   Characterization of helical cleavages in type II collagen generated by matrixins [J].
Vankemmelbeke, M ;
Dekeyser, PM ;
Hollander, AP ;
Buttle, DJ ;
Demeester, J .
BIOCHEMICAL JOURNAL, 1998, 330 :633-640