Effect of a dentifrice containing the peptide of streptococcal antigen I/II on the adherence of mutans streptococcus

被引：11
作者：
Li, Ming-Yu [1 ]
Wang, Jun [1 ]
Lai, Guang-Yun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Coll Med, Peoples Hosp 9, Shanghai Res Inst Stomatol,Shanghai Key Lab Stoma, Shanghai 200011, Peoples R China
来源：
ARCHIVES OF ORAL BIOLOGY | 2009年 / 54卷 / 11期
关键词：
Peptide; Adherence; Mutans streptococcus; Dentifrice; PROTEIN ANTIGENS; ADHESION; ADSORPTION;
D O I：
10.1016/j.archoralbio.2009.08.004
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective: Antigen I/II of mutans streptococcus (MS) is a surface protein, which binds to salivary receptors. The objective of this study was to study the effect of a peptide corresponding to residues 1025-1044 of antigen I/II and a dentifrice containing peptide on the adherence of MS. Methods: The peptide was synthesized and included into dentifrice. Anti-adherence experiments of the peptide and a dentifrice containing it were processed in vitro and in vivo. Results: The results showed that the adherence of MS to hydroxyapatite was inhibited by synthetic antigen I/II peptide and also by a dentifrice containing the peptide in vitro. The numbers of MS in plaque from subjects treated with dentifrices containing the peptide for 1 month was significantly reduced compared to baseline (log 3.11 +/- 0.80 vs log 4.09 +/- 0.90, P < 0.01), whereas the control group showed no reduction. Conclusion: The adherence of MS to hydroxyapatite was inhibited by both a synthetic peptide and a dentifrice containing the peptide. The peptide dentifrice produced a significant reduction of MS in dental plaque in vivo. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1068 / 1073
页数：6
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