Effect of a dentifrice containing the peptide of streptococcal antigen I/II on the adherence of mutans streptococcus

Objective: Antigen I/II of mutans streptococcus (MS) is a surface protein, which binds to salivary receptors. The objective of this study was to study the effect of a peptide corresponding to residues 1025-1044 of antigen I/II and a dentifrice containing peptide on the adherence of MS. Methods: The peptide was synthesized and included into dentifrice. Anti-adherence experiments of the peptide and a dentifrice containing it were processed in vitro and in vivo. Results: The results showed that the adherence of MS to hydroxyapatite was inhibited by synthetic antigen I/II peptide and also by a dentifrice containing the peptide in vitro. The numbers of MS in plaque from subjects treated with dentifrices containing the peptide for 1 month was significantly reduced compared to baseline (log 3.11 +/- 0.80 vs log 4.09 +/- 0.90, P < 0.01), whereas the control group showed no reduction. Conclusion: The adherence of MS to hydroxyapatite was inhibited by both a synthetic peptide and a dentifrice containing the peptide. The peptide dentifrice produced a significant reduction of MS in dental plaque in vivo. (C) 2009 Elsevier Ltd. All rights reserved.