The Expression and Prognostic Role of Hepatoma-Derived Growth Factor in Colorectal Stromal Tumors

被引:32
作者
Hu, Tsung-Hui [2 ]
Lin, Jui-Wei [3 ]
Chen, Hong-Hwa [4 ]
Liu, Li-Feng [5 ]
Chuah, Seng-Kee [2 ]
Tai, Ming-Hong [1 ,6 ]
机构
[1] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 804, Taiwan
[2] Chang Gung Univ, Div Hepatogastroenterol, Dept Internal Med, Chang Gung Mem Hosp,Kaohsiung Med Ctr,Coll Med, Kaohsiung, Taiwan
[3] Chang Gung Univ, Chang Gung Mem Hosp, Dept Pathol, Kaohsiung Med Ctr,Coll Med, Kaohsiung, Taiwan
[4] Chang Gung Univ, Chang Gung Mem Hosp, Dept Surg, Div Colorectal Surg,Kaohsiung Med Ctr,Coll Med, Kaohsiung, Taiwan
[5] I Shou Univ, Dept Biol Sci & Technol, Kaohsiung, Taiwan
[6] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung, Taiwan
关键词
Hepatoma-derived growth factor; Colon and rectum; Gastrointestinal stromal tumors; Ki-67; Proliferating cell nuclear antigen; Prognosis; HEPATOCELLULAR-CARCINOMA; DIFFERENTIAL-DIAGNOSIS; DNA; INDEX; RAT; KIT; IDENTIFICATION; PROLIFERATION; MUTATIONS; PROTEIN;
D O I
10.1007/DCR.0b013e31819d1666
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
PURPOSE: This study investigated the expression and prognostic role of hepatoma-derived growth factor (HDGF) in colorectal stromal tumor. METHODS: Fifty-two surgically resected colorectal stromal tumors were collected from 1986 to 2006. Immunohistochemical studies were performed with antibodies of HDGF, proliferating cell nuclear antigen (PCNA) and Ki-67. RESULTS: Sixteen patients (30.7 percent) had positive Ki-67 immunostaining. Immunoreactivity to PCNA ranged from 10 to 93 percent. HDGF immunostaining was found in the nucleus (20-95 percent) as well as in the cytoplasm (weak: 16; intermediate: 17; strong: 19). Upregulation of nuclear HDGF levels existed in increased cytoplasmic HDGF levels (P < 0.001). Nuclear HDGF levels were positively correlated with tumor mitotic count (P < 0.001), tumor size (P = 0.002), PCNA (P < 0.001), Ki-67 (P = 0.049), cellular pleomorphism (P = 0.029), and increased National Institutes of Health risk level (P = 0.037). Cytoplasmic HDGF levels were also correlated with PCNA (P = 0.001), tumor mitotic count (P = 0.001), high cellular pleomorphism (P = 0.001), and increased NIH risk (P = 0.043). Kaplan-Meier analyses revealed that patients with high nuclear HDGF (P < 0.001) or cytoplasmic levels (P = 0.001) had shorter disease-free survival than patients with low HDGF levels. Like tumor mitotic count, nuclear HDGF was an independent prognostic factor for patients with colorectal stromal tumors. CONCLUSIONS: This study provides clinicopathologic correlations and prognostic prediction of HDGF expression for the relatively rare colorectal stromal tumors.
引用
收藏
页码:319 / 326
页数:8
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