The clinical value of neutrophil extracellular traps

被引：95

作者：

Loegters, Tim ^{[1
]}

Margraf, Stefan ^{[1
]}

Altrichter, Jens ^{[1
]}

Cinatl, Jindrich ^{[2
]}

Mitzner, Steffen ^{[3
]}

Windolf, Joachim ^{[1
]}

Scholz, Martin ^{[1
]}

机构：

[1] Univ Dusseldorf, Dept Trauma & Hand Surg, D-40225 Dusseldorf, Germany

[2] Goethe Univ Frankfurt, Inst Med Virol, Frankfurt, Germany

[3] Univ Rostock, Dept Internal Med, Div Nephrol, D-2500 Rostock, Germany

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2009年 / 198卷 / 04期

关键词：

Neutrophils; Innate immunity; Pathophysiology; Neutrophil extracellular traps; SYSTEMIC-LUPUS-ERYTHEMATOSUS; STREPTOCOCCUS-PNEUMONIAE; CYSTIC-FIBROSIS; INFLAMMATORY RESPONSE; VIRUS-INFECTION; HOST-DEFENSE; LUNG INJURY; CELL-DEATH; FREE DNA; SEPSIS;

D O I：

10.1007/s00430-009-0121-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.

引用

页码：211 / 219

页数：9

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