Increased Type 5 Adenylyl Cyclase Expression Mediates Chronic Catecholamine Stress via Increases in Oxidative Stress and Down-regulation of MnSOD

被引:0
|
作者
Lai, Lo [1 ]
Yen, Lin [1 ]
Hu, Che-Lin [1 ]
Gao, Shumin [1 ]
Iwatsubo, Kosaku [1 ]
Ishkawa, Yoshihiro [1 ]
Sadoshima, Junichi [1 ]
Vatner, Stephen F. [1 ]
Vatner, Dorothy E. [1 ]
机构
[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S781 / S781
页数:1
相关论文
共 50 条
  • [1] Down-regulation of MnSOD via Sirt1/FoxO3a complex increase oxidative stress with cardiac overexpression of Type 5 Adenylyl Cyclase
    Lai, Lo
    Yan, Lin
    Hu, Che-Lin
    Gao, Shumin
    Iwatsubo, Kosaku
    Ishikawa, Yoshihiro
    Sadoshima, Junichi
    Vatner, Stephen F.
    Vatner, Dorothy E.
    FASEB JOURNAL, 2010, 24
  • [2] Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the Sirt1/FoxO3a Pathway
    Lai, Lo
    Yan, Lin
    Hu, Che Lin
    Gao, Shumin
    Ge, Hui
    Iwatsubo, Kosaku
    Vatner, Stephen F.
    Vatner, Dorothy E.
    CIRCULATION, 2012, 126 (21)
  • [3] Increased Oxidative Stress and Apoptosis as Mechanisms for Adverse Effects of Chronic Pressure Overload and Catecholamine Stress in Mice with Cardiac Overexpression of Type 5 Adenylyl Cyclase
    Lai, Lo
    Yan, Lin
    Hu, Che-Lin
    Gao, Shumin
    Hong, Chull
    Vatner, Stephen F.
    Vatner, Dorothy E.
    CIRCULATION, 2008, 118 (18) : S297 - S297
  • [4] Pharmacological Inhibition of Type 5 Adenylyl Cyclase Attenuates Functional Deterioration in Chronic Catecholamine Stress
    Iwatsubo, Kosaku
    Baljinnyam, Erdene
    Gao, Shumin
    Sadoshima, Junichi
    Vatner, Dorothy E.
    Vatner, Stephen F.
    Ishikawa, Yoshihiro
    CIRCULATION, 2008, 118 (18) : S542 - S542
  • [5] Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress
    Okumura, Satoshi
    Vatner, Dorothy E.
    Kurotani, Reiko
    Bai, Yunzhe
    Gao, Shumin
    Yuan, Zengrong
    Iwatsubo, Kousaku
    Ulucan, Coskun
    Kawabe, Jun-ichi
    Ghosh, Kaushik
    Vatner, Stephen F.
    Ishikawa, Yoshihlro
    CIRCULATION, 2007, 116 (16) : 1776 - 1783
  • [6] Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection
    Vatner, Stephen F.
    Pachon, Ronald E.
    Vatner, Dorothy E.
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 2015
  • [7] Type 5 adenylyl cyclase disruption increases longevity and protects against stress
    Yan, Lin
    Vatner, Dorothy E.
    O'Connor, J. Patrick
    Ivessa, Andreas
    Ge, Hui
    Chen, Wei
    Hirotani, Shinichi
    Ishikawa, Yoshihiro
    Sadoshima, Junichi
    Vatner, Stephen F.
    CELL, 2007, 130 (02) : 247 - 258
  • [8] Type 5 adenylyl cyclase disruption increases longevity and protects against stress
    Yan, L
    Vatner, DE
    Liu, J
    Thaisz, J
    O'Connor, JP
    Brimacombe, M
    Ge, H
    Chen, W
    Ishikawa, Y
    Vatner, SF
    CIRCULATION, 2005, 112 (17) : U109 - U109
  • [9] Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway
    Lai, Lo
    Yan, Lin
    Gao, Shumin
    Hu, Che-Lin
    Ge, Hui
    Davidow, Amy
    Park, Misun
    Bravo, Claudio
    Iwatsubo, Kousaku
    Ishikawa, Yoshihiro
    Auwerx, Johan
    Sinclair, David A.
    Vatner, Stephen F.
    Vatner, Dorothy E.
    CIRCULATION, 2013, 127 (16) : 1692 - +
  • [10] Disruption of type 5 adenylyl cyclase enhances desensitization of the camp signal and increases the Akt signal following chronic catecholamine stress, protecting myocyte viability
    Okumura, S
    Liu, J
    Yang, GP
    Ulucan, C
    Tsunematsu, T
    Kawabe, J
    Ishikawa, Y
    CIRCULATION, 2005, 112 (17) : U313 - U313