Treatment of Neuromyelitis Optica Spectrum Disorder: Acute, Preventive, and Symptomatic

被引：120

作者：

Kessler, Remi A. ^{[1
]}

Mealy, Maureen A. ^{[1
]}

Levy, Michael ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, 600 N Wolfe St, Baltimore, MD 21287 USA

来源：

CURRENT TREATMENT OPTIONS IN NEUROLOGY | 2016年 / 18卷 / 01期

关键词：

Neuromyelitis optica spectrum disorder; Immunosuppression; Azathioprine; Mycophenolate; Rituximab; Eculizumab; MYCOPHENOLATE-MOFETIL; MULTIPLE-SCLEROSIS; PLASMA-EXCHANGE; ACUTE RELAPSES; DOUBLE-BLIND; AZATHIOPRINE; EFFICACY; THERAPY; MULTICENTER; FATIGUE;

D O I：

10.1007/s11940-015-0387-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system that primarily attacks the optic nerves and spinal cord leading to blindness and paralysis. The spectrum of the disease has expanded based on the specificity of the autoimmune response to the aquaporin-4 water channel on astrocytes. With wider recognition of NMOSD, a standard of care for treatment of this condition has condition based on a growing series of retrospective and prospective studies. This review covers the present state of the field in the treatment of acute relapses, preventive approaches, and therapies for symptoms of NMOSD.

引用

页码：1 / 15

页数：15

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