A novel κ-opioid receptor agonist, TRK-820 blocks the development of physical dependence on morphine in mice

被引：27

作者：

Tsuji, M

Takeda, H

Matsumiya, T

Nagase, H

Yamazaki, M

Narita, M

Suzuki, T

机构：

[1] Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan

[2] Tokyo Med Coll, Dept Pharmacol, Shinjyuku Ku, Tokyo 1608402, Japan

[3] Toray Ind Inc, Basic Res Labs, Kamakura, Kanagawa 2488555, Japan

[4] Toyama Med & Pharmaceut Univ, Intens Care Unit, Toyama 93001, Japan

来源：

LIFE SCIENCES | 2000年 / 66卷 / 25期

关键词：

kappa-opioid receptor agonist; TRK-820; physical dependence; morphine; mouse;

D O I：

10.1016/S0024-3205(00)80011-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of a novel kappa-opioid receptor agonist, TRK-820, on the development of physical dependence on morphine were investigated in mice in comparison with those of U-50,488H. A marked body weight loss and several withdrawal signs were observed following naloxone challenge in morphine-dependent mice. Go-injection of TRK-820 (0.003-0.03 mg/kg, s.c.) but not U-50,488H (1-10 mg/kg, s.c.) during chronic morphine treatment dose-dependently suppressed the naloxone-precipitated body weight loss, jumping, wet dog shakes and diarrhea. These results suggest that TRK-820-sensitive kappa -opioid receptor subtypes may play a significant role in modulating the development of physical dependence on morphine. (C) 2000 Elsevier Science Inc.

引用

页码：PL353 / PL358

页数：6

共 20 条

[1] DYNORPHIN IS A SPECIFIC ENDOGENOUS LIGAND OF THE KAPPA-OPIOID RECEPTOR [J].