Molecular Pathology of Myeloproliferative Neoplasms

被引：15
作者：
Klco, Jeffery M. [1 ]
Vij, Ravi [2 ]
Kreisel, Friederike H. [1 ]
Hassan, Anjum [1 ]
Frater, John L. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Pathol & Immunol, Bone Marrow Transplantat Sect,Div Oncol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Med, Bone Marrow Transplantat Sect,Div Oncol, St Louis, MO 63110 USA
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2010年 / 133卷 / 04期
关键词：
Molecular pathology; Myeloproliferative neoplasms; Chronic myelogenous leukemia; Chronic neutrophilic leukemia; Polycytnemia vera; Primary myelofibrosis; Essential thrombocythemia; Chronic eosinophilic leukemia; Mastocytosis; Myeloproliferative neoplasm; unclassifiable; CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; JAK2 V617F MUTATION; POLYMERASE-CHAIN-REACTION; GROWTH-FACTOR RECEPTOR; ABL FUSION TRANSCRIPT; CHRONIC GRANULOCYTIC LEUKEMIA; TYROSINE KINASE INHIBITOR; JAK2V617F ALLELE BURDEN; C-KIT MUTATION;
D O I：
10.1309/AJCPPPZ1WFVGNE4A
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Myeloproliferative neoplasms (MPNs; formerly chronic myeloproliferative disorders) are a class of myeloid hematologic malignancies that represent a stem cell-derived expansion of 1 or more hematopoietic cell lineages The current 2008 World Health Organization system recognizes 8 types of MPNl; chronic myelogenous leukemia, chronic neutrophilic leukemia, polycythemia vera, primary myelofibrosis, essential thrombocythemia, chronic eosinophilic leukemia mastocytosis and myeloproliferative neoplasm, unclassifiable This review summarizes the salient characteristics of the MPNs, with emphasis on recent developments in the molecular pathophysiology and therapeutic monitoring of these disorders.
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收藏
页码：602 / 615
页数：14
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