Molluscicidal activity of cardiac glycosides isolated from Adenium obesum

被引：4

作者：

Alzabib, Ali A. ^{[1
]}

Abobakr, Yasser ^{[1
,2
]}

Al-Sarar, Ali S. ^{[1
]}

Hussein, Hamdy I. ^{[2
]}

Basudan, Omer A. ^{[3
]}

El-Gamal, Ali A. ^{[3
]}

Abdel-Kader, Maged S. ^{[4
]}

El Komy, Mahmoud H. ^{[1
,5
]}

机构：

[1] King Saud Univ, Coll Food & Agr Sci, Dept Plant Protect, Riyadh 11451, Saudi Arabia

[2] Agr Res Ctr, Sabahia Res Stn, Plant Protect Res Inst, Dept Anim Pests, Alexandria, Egypt

[3] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia

[4] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj, Saudi Arabia

[5] ARC, Plant Pathol Inst, Dept Mycol & Plant Dis Survey, Alexandria, Egypt

来源：

PEST MANAGEMENT SCIENCE | 2019年 / 75卷 / 10期

关键词：

Adenium obesum; molluscicidal activity; cardiac glycosides; cerberin; neriifolin; METALDEHYDE; CERBERA; SNAIL; CONSTITUENTS; METHIOCARB; METHOMYL; LEAVES; SEEDS;

D O I：

10.1002/ps.5388

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

BACKGROUND Terrestrial mollusks are one of most important agricultural pests worldwide. Natural phytochemicals have an extended history as a source of pesticides. This study was planned to isolate molluscicidal active compounds from the stems of Adenium obesum. RESULTS The benzene-soluble fraction of the hydroethanolic extract displayed the most potent molluscicidal activity against Monacha obstructa among different solvent fractions with a median lethal dose (LD50) of 4.91 mu g g(-1) body weight (bw). The bioactivity-guided chemical exploration of the benzene-soluble fraction led to the isolation of two known cardiac glycosides, cerberin and neriifolin which showed significant molluscicidal activity with LD50 values of 5.39 and 4.3 mu g g(-1) bw, respectively. CONCLUSION Isolation of the cardiac glycoside neriifolin from A. obesum and the molluscicidal activity of cerberin and neriifolin against terrestrial snails are reported for the first time. (c) 2019 Society of Chemical Industry

引用

页码：2770 / 2775

页数：6

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