Unstable Propoxyphene Metabolite Excreted in Human Urine is Detected by Liquid Chromatography-Tandem Mass Spectrometry

被引：4

作者：

Crews, Bridgit ^{[1
]}

Mikel, Charles ^{[1
]}

Latyshev, Sergey ^{[1
]}

West, Robert ^{[1
]}

Pesce, Amadeo ^{[1
]}

机构：

[1] Millennium Labs, San Diego, CA 92117 USA

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 2009年 / 33卷 / 07期

关键词：

D O I：

10.1093/jat/33.7.379

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A "dilute and shoot" method for measuring norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). The metabolite formed from the rearrangement and dehydration of norpropoxyphene is excreted in human urine and also may be formed from the chemical degradation of norpropoxyphene. Previously, these two metabolites were indistinguishable by gas chromatography-mass spectrometry methods that use an alkaline extraction that converts norpropoxyphene into its rearrangement product. The degradation of norpropoxyphene presents a challenge for its analytical quantitation, and methods for circumventing these issues are presented.

引用

页码：379 / 383

页数：5

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