Clinical Applications of Personalized Medicine: A New Paradigm and Challenge

被引:87
作者
Di Sanzo, Mariantonia [1 ]
Cipolloni, Luigi [1 ,2 ]
Borro, Marina [3 ]
La Russa, Raffaele [1 ,4 ]
Santurro, Alessandro [1 ]
Scopetti, Matteo [1 ]
Simmaco, Maurizio [3 ]
Frati, Paola [1 ,4 ]
机构
[1] Sapienza Univ Rome, Dept Anat Histol Forens & Orthopaed Sci SAIMLAL, Viale Regina Elena 336, I-00185 Rome, Italy
[2] IRCCS Neuromed, Via Atinense 18, I-86077 Pozzilli, Italy
[3] Sapienza Univ Rome, Dept Neurosci Mental Hlth & Sensory Organs NESMOS, Via Grottarossa 1035, I-00189 Rome, Italy
[4] Malzoni Clin Sci Inst MaCSI, Via Carmelo Errico 2, I-83100 Avellino, Italy
关键词
Personalized medicine; genetic tests; precision medicine; medicine system; genomic medicine; molecular diagnostic; pharmacogenomics; healthcare; STAR-ASTERISK-D; PRECISION MEDICINE; ANTIDEPRESSANT TREATMENT; CARDIOVASCULAR-DISEASE; SYSTEMS MEDICINE; BLOOD-PRESSURE; HEALTH-CARE; POLYMORPHISM; GENE; ASSOCIATION;
D O I
10.2174/1389201018666170224105600
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The personalized medicine is an emergent and rapidly developing method of clinical practice that uses new technologies to provide decisions in regard to the prediction, prevention, diagnosis and treatment of disease. A continuous evolution of technology and the developments in molecular diagnostics and genomic analysis increased the possibility of an even more understanding and interpretation of the human genome and exome, allowing a "personalized" approach to clinical care, so that the concepts of "Systems Medicine" and "System Biology" are actually increasing. The purpose of this study is to evaluate the personalized medicine about its indications and benefits, actual clinical applications and future perspectives as well as its issues and health care implications. A careful review of the scientific literature on this field that highlighted the applicability and usefulness of this new medical approach as well as the fact that personalized medicine strategy is even more increasing in numerous fields of applications.
引用
收藏
页码:194 / 203
页数:10
相关论文
共 67 条
[1]   Genotype-Based Ancestral Background Consistently Predicts Efficacy and Side Effects across Treatments in CATIE and STAR*D [J].
Adkins, Daniel E. ;
Souza, Renan P. ;
Aberg, Karolina ;
Clark, Shaunna L. ;
McClay, Joseph L. ;
Sullivan, Patrick F. ;
van den Oord, Edwin J. C. G. .
PLOS ONE, 2013, 8 (02)
[2]   From big data analysis to personalized medicine for all: challenges and opportunities [J].
Alyass, Akram ;
Turcotte, Michelle ;
Meyre, David .
BMC MEDICAL GENOMICS, 2015, 8
[3]  
[Anonymous], TARG CANC THER FACT
[4]  
[Anonymous], 2008, Report of the President's Council of Advisors on Science and Technology. Priorities for Personalized Medicine
[5]  
Auffray C, 2016, GENOME MED, V8, DOI [10.1186/s13073-016-0323-y, 10.1186/s13073-016-0265-4]
[6]   Sharpening Precision Medicine by a Thorough Interrogation of Metabolic Individuality [J].
Beebe, Kirk ;
Kennedy, Adam D. .
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2016, 14 :97-105
[7]   Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics [J].
Beitelshees, Amber L. ;
Voora, Deepak ;
Lewis, Joshua P. .
PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2015, 8 :43-61
[8]   Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial [J].
Bhatnagar, Vibha ;
O'Connor, Daniel T. ;
Schork, Nicholas J. ;
Salem, Rany M. ;
Nievergelt, Caroline M. ;
Rana, Brinda K. ;
Smith, Douglas W. ;
Bakris, George L. ;
Middleton, John P. ;
Norris, Keith C. ;
Wright, Jackson T. ;
Cheek, Deanna ;
Hiremath, Leena ;
Contreras, Gabriel ;
Appel, Lawrence J. ;
Lipkowitz, Michael S. .
JOURNAL OF HYPERTENSION, 2007, 25 (10) :2082-2092
[9]   Genetic Variation in the CYP2D6 Gene Is Associated With a Lower Heart Rate and Blood Pressure in β-Blocker Users [J].
Bijl, M. J. ;
Visser, L. E. ;
van Schaik, R. H. N. ;
Kors, J. A. ;
Witteman, J. C. M. ;
Hofman, A. ;
Vulto, A. G. ;
van Gelder, T. ;
Stricker, B. H. Ch .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 85 (01) :45-50
[10]   Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants [J].
Bijl, Monique J. ;
Visser, Loes E. ;
Hofman, Albert ;
Vulto, Arnold G. ;
van Gelder, Teun ;
Stricker, Bruno H. Ch. ;
van Schaik, Ron H. N. .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 65 (04) :558-564