Local radiofrequency-induced hyperthermia using CuNi nanoparticles with therapeutically suitable Curie temperature

Copper-nickel (CuNi) alloy nanoparticles with Curie temperatures (T-c) from 40 to 60 degrees C were synthesized by several techniques. Varying the synthesis parameters and post-treatment, as well as separations by size and T-c, allow producing mediator nanoparticles for magnetic fluid hyperthermia with parametric feedback temperature control with desired parameters. In vitro and in vivo animal experiments have demonstrated the feasibility of the temperature-controlled heating of the tissue, laden with the particles, by an external alternating magnetic field. (C) 2006 Elsevier B.V. All rights reserved.