Toll-like Receptor 9: AEP Takes Control

被引：4

作者：

van Endert, Peter ^{[1
,2
]}

机构：

[1] INSERM, U580, F-75015 Paris, France

[2] Univ Paris 05, F-75015 Paris, France

来源：

IMMUNITY | 2009年 / 31卷 / 05期

关键词：

ASPARAGINYL ENDOPEPTIDASE; COMPARTMENT; CATHEPSINS; MICE;

D O I：

10.1016/j.immuni.2009.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor 9 (TLR9) requires proteolytic maturation to acquire signaling capacity; however, the involved protease(s) is unclear. In this issue of Immunity, Sepulveda et al. (2009) demonstrate that in dendritic cells, asparaginyl endopeptidase is a key protease that controls TLR9 maturation.

引用

页码：696 / 698

页数：3

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