Toll-like Receptor 9: AEP Takes Control

被引：4

作者：

van Endert, Peter ^{[1
,2
]}

机构：

[1] INSERM, U580, F-75015 Paris, France

[2] Univ Paris 05, F-75015 Paris, France

来源：

IMMUNITY | 2009年 / 31卷 / 05期

关键词：

ASPARAGINYL ENDOPEPTIDASE; COMPARTMENT; CATHEPSINS; MICE;

D O I：

10.1016/j.immuni.2009.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor 9 (TLR9) requires proteolytic maturation to acquire signaling capacity; however, the involved protease(s) is unclear. In this issue of Immunity, Sepulveda et al. (2009) demonstrate that in dendritic cells, asparaginyl endopeptidase is a key protease that controls TLR9 maturation.

引用

页码：696 / 698

页数：3

共 10 条

[1] Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis [J].

Asagiri, Masataka ;

Hirai, Toshitake ;

Kunigami, Toshihiro ;

Kamano, Shunya ;

Gober, Hans-Juergen ;

Okamoto, Kazuo ;

Nishikawa, Keizo ;

Latz, Eicke ;

Golenbock, Douglas T. ;

Aoki, Kazuhiro ;

Ohya, Keiichi ;

Imai, Yuuki ;

Morishita, Yasuyuki ;

Miyazono, Kohei ;

Kato, Shigeaki ;

Saftig, Paul ;

Takayanagi, Hiroshi .

SCIENCE, 2008, 319 (5863) :624-627

[2] A cell biological view of Toll-like receptor function: regulation through compartmentalization [J].

Barton, Gregory M. ;

Kagan, Jonathan C. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (08) :535-542

[3]

Ewald SE, 2008, NATURE, V456, P658, DOI 10.1038/nature07405

[4] Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice [J].

Maehr, R ;

Hang, HC ;

Mintern, JD ;

Kim, YM ;

Cuvillier, A ;

Nishimura, M ;

Yamada, K ;

Shirahama-Noda, K ;

Hara-Nishimura, I ;

Ploegh, HL .

JOURNAL OF IMMUNOLOGY, 2005, 174 (11) :7066-7074

[5] Cathepsins are required for toll-like receptor 9 responses [J].

Matsumoto, Fumi ;

Saitoh, Shin-ichiroh ;

Fukui, Ryutaroh ;

Kobayashi, Toshihiko ;

Tammura, Natsuko ;

Konnio, Kazunori ;

Kusumoto, Yutaka ;

Akashi-Takamura, Sachiko ;

Miyake, Kensuke .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (03) :693-699

[6] Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo [J].

Ni, DTN ;

Matthews, SP ;

Antoniou, AN ;

Mazzeo, D ;

Watts, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) :38980-38990

[7] Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 [J].

Park, Boyoun ;

Brinkmann, Melanie M. ;

Spooner, Eric ;

Lee, Clarissa C. ;

Kim, You-Me ;

Ploegh, Hidde L. .

NATURE IMMUNOLOGY, 2008, 9 (12) :1407-1414

[8] Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells [J].

Sepulveda, Fernando E. ;

Maschalidi, Sophia ;

Colisson, Renaud ;

Heslop, Lea ;

Ghirelli, Cristina ;

Sakka, Emna ;

Lennon-Dumenil, Ana-Maria ;

Amigorena, Sebastian ;

Cabanie, Lucien ;

Manoury, Benedicte .

IMMUNITY, 2009, 31 (05) :737-748

[9] Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice [J].

Shirahama-Noda, K ;

Yamamoto, A ;

Sugihara, K ;

Hashimoto, N ;

Asano, M ;

Nishimura, M ;

Hara-Nishimura, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (35) :33194-33199

[10] Asparaginyl endopeptidase: case history of a class II MHC compartment protease [J].

Watts, C ;

Matthews, SP ;

Mazzeo, D ;

Manoury, B ;

Moss, CX .

IMMUNOLOGICAL REVIEWS, 2005, 207 :218-228

← 1 →