PREPARATION OF N-PHENYL-SUBSTITUTED QUINOLINIUM DERIVATIVES LABELED WITH TRITIUM BY CHEMONUCLEAR SYNTHESIS

被引：7

作者：

Shchepina, N. E. ^{[1
]}

Avrorin, V. V. ^{[2
]}

Badun, G. A. ^{[3
]}

Alexandrova, G. A. ^{[1
]}

Ukhanov, S. E. ^{[4
]}

Fedoseev, V. M. ^{[3
]}

Lewis, S. B. ^{[5
]}

Boiko, I. I. ^{[6
]}

机构：

[1] Perm State Univ, Inst Nat Sci, Perm 614990, Russia

[2] St Petersburg State Univ, St Petersburg 199034, Russia

[3] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

[4] Perm State Tech Univ, Perm 614600, Russia

[5] James Madison Univ, Harrisonburg, VA 22807 USA

[6] Tekhnolog, Pereslavl Zalesskii 152025, Yaroslavl Reg, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 07期

关键词：

N-phenylquinolinium and quinaldinium salts; tritium; phenyl cations; six-membered nitrogen heterocyclic compounds; chemonuclear synthesis; INHIBITION; OXIDASE; SALTS;

D O I：

10.1007/s10593-009-0359-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemonuclear method of synthesis is proposed for obtaining difficultly available phenyl-substituted derivatives of quinoline labeled with tritium. The ion-molecule reaction of free phenyl cations, generated on beta-decay of tritium, with the nucleophilic centers of heterocyclic compounds is the basis of the synthesis. The onium derivatives synthesized possess significant inhibitory antimicrobial activity and are promising for a detailed study of the reaction mechanisms and metabolic processes using radioactive indicators.

引用

页码：796 / 801

页数：6

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