Presence of ROB-1 β-lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae

被引：25

作者：

Karlowsky, JA

Verma, G

Zhanel, GG

Hoban, DJ

机构：

[1] Hlth Sci Ctr, Dept Clin Microbiol, Winnipeg, MB R3A 1R9, Canada

[2] Hlth Sci Ctr, Dept Med, Winnipeg, MB R3A 1R9, Canada

[3] Univ Manitoba, Fac Pharm, Winnipeg, MB R3T 2N2, Canada

[4] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3T 2N2, Canada

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 45卷 / 06期

关键词：

D O I：

10.1093/jac/45.6.871

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

beta-Lactamase production in Canadian isolates of Haemophilus influenzae has remained relatively constant (25-35%) over the last decade despite increasing cefaclor resistance (MIC greater than or equal to 32 mg/L). TEM (294/324, 90.7%) and ROB-1 (30/324, 9.3%) prevalence rates among 324 isolates of H. influenzae obtained from across Canada in 1997-1998 were similar (P > 0.05) to previously published reports. However, 66.7% (26/39) of cefaclor-resistant isolates were ROB-1-positive (P < 0.001) and the remaining four ROB-1-positive isolates were cefaclor-intermediate (MIC 16 mg/L). Susceptibilities to loracarbef (P < 0.001) and cefprozil were also reduced in the presence of ROB-1 while the activities of cefuroxime, cefotaxime, cefixime and imipenem were similar in both TEM- and ROB-1-positive isolates.

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收藏

页码：871 / 875

页数：5

相关论文

共 10 条

[1] CLASSIFICATION OF BETA-LACTAMASES - GROUP-1, GROUP-2A, GROUP-2B, AND GROUP-2B' [J].

BUSH, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (03) :264-270

[2] EPIDEMIOLOGY OF ROB BETA-LACTAMASE AMONG AMPICILLIN-RESISTANT HEMOPHILUS-INFLUENZAE ISOLATES IN THE UNITED-STATES [J].

DAUM, RS ;

MURPHEYCORB, M ;

SHAPIRA, E ;

DIPP, S .

JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (03) :450-455

[3] Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections:: Antimicrobial susceptibility patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997) [J].

Doern, GV ;

Jones, RN ;

Pfaller, MA ;

Kugler, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (02) :385-389

[4] In vitro activity of the novel ketolide HMR 3647 and comparative oral antibiotics against Canadian respiratory tract isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis [J].

Hoban, DJ ;

Zhanel, GG ;

Karlowsky, JA .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1999, 35 (01) :37-44

[5] A 1994-95 survey of Haemophilus influenzae susceptibility to ten orally administered agents - A 187 clinical laboratory center sample in the United States [J].

Jones, RN ;

Jacobs, MR ;

Washington, JA ;

Pfaller, MA .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1997, 27 (03) :75-83

[6]

*NAT COMM CLIN LAB, 1999, PERF STAND ANT SUSC

[7] DETERMINATION OF ANTIMICROBIAL SUSCEPTIBILITIES OF CANADIAN ISOLATES OF HAEMOPHILUS-INFLUENZAE AND CHARACTERIZATION OF THEIR BETA-LACTAMASES [J].

SCRIVER, SR ;

WALMSLEY, SL ;

KAU, CL ;

HOBAN, DJ ;

BRUNTON, J ;

MCGEER, A ;

MOORE, TC ;

WITWICKI, E ;

ABBOTT, LP ;

ALFA, M ;

ANAND, D ;

ANDERSON, J ;

BERGERON, MG ;

BLONDEAU, J ;

CLARKE, AM ;

DIAZMITOMA, F ;

FORWARD, K ;

GREGSON, D ;

HORSMEN, GB ;

JESSAMINE, P ;

KIBSEY, P ;

KUHN, M ;

LAVADIERE, M ;

MARTIN, T ;

MCDONALD, JC ;

MCNAUGHTON, RD ;

SMITH, J ;

ZOUTMAN, D ;

LOW, DE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) :1678-1680

[8] NUCLEOTIDE-SEQUENCE OF AMPICILLIN RESISTANCE GENE OF ESCHERICHIA-COLI PLASMID PBR322 [J].

SUTCLIFFE, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) :3737-3741

[9]

WALMSLEY SL, 1990, 90 ANN M AM SOC MICR, P13

[10] THE INVITRO ACTIVITY OF CEFPODOXIME - A COMPARISON WITH OTHER ORAL CEPHALOSPORINS [J].

WISE, R ;

ANDREWS, JM ;

ASHBY, JP ;

THORNBER, D .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 (04) :541-550