Dehydrogenative alcohol coupling and one-pot cross metathesis/dehydrogenative coupling reactions of alcohols using Hoveyda-Grubbs catalysts

被引：4

作者：

Ozer, Halenur ^{[1
]}

Arslan, Dilan ^{[1
]}

Ozturk, Bengi Ozgun ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Sci, Chem Dept, TR-06800 Beytepe, Turkey

来源：

NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 13期

关键词：

METATHESIS CATALYST;

D O I：

10.1039/d1nj00255d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, in situ formed ruthenium hydride species that were generated from Grubbs type catalysts are used as efficient catalysts for dehydrogenative alcohol coupling and sequential cross-metathesis/dehydrogenative coupling reactions. The selectivity of Grubbs first generation catalysts (G1) in dehydrogenative alcohol coupling reactions can be tuned for the ester formation in the presence of weak bases, while the selectivity can be switched to the beta-alkylated alcohol formation using strong bases. The performance of Hoveyda-Grubbs 2nd generation catalyst (HG2) was improved in the presence of tricyclohexylphosphine for the selective synthesis of ester derivatives with weak and strong bases in quantitative yields. Allyl alcohol was used as self and cross-metathesis substrate for the HG2 catalyzed sequential cross-metathesis/dehydrogenative alcohol coupling reactions to obtain gamma-butyrolactone and long-chain ester derivatives in quantitative yields.

引用

页码：5992 / 6000

页数：9

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