Epidemiological profile and molecular genetic characterization of HIV-1 among female sex workers and elderly male clients in Guangxi, China

被引:26
作者
Chen, Xiu [1 ,2 ]
Qin, Chunwei [3 ]
Chen, Rongfeng [1 ,2 ]
Huang, Yunxuan [3 ]
Xu, Yuexiang [3 ]
Tang, Qiao [2 ]
Liang, Xianjun [3 ]
Peng, Bing [4 ]
Shao, Yi [5 ]
Yang, Yao [2 ]
Chen, Jie [1 ,2 ]
Wang, Xinwei [2 ]
Wen, Liufang [2 ]
Liang, Bingyu [1 ]
Ye, Li [1 ,2 ]
Qin, Xionglin [3 ]
Jiang, Junjun [1 ,2 ]
Liang, Hao [1 ,2 ]
机构
[1] Guangxi Med Univ, Life Sci Inst, Guangxi ASEAN Collaborat Innovat Ctr Major Dis Pr, Nanning 530021, Guangxi, Peoples R China
[2] Guangxi Med Univ, Sch Publ Hlth, Guangxi Key Lab AIDS Prevent & Treatment, Nanning 530021, Guangxi, Peoples R China
[3] Guigang Ctr Dis Control & Prevent, Guigang 537100, Guangxi, Peoples R China
[4] Peoples Hosp Guigang, Guigang 537100, Guangxi, Peoples R China
[5] Guigang Maternal & Child Hlth Hosp, Guigang 537100, Guangxi, Peoples R China
关键词
HIV; AIDS; female sex workers; elderly male clients; molecular epidemiology; transmission network; TRANSMISSION; DISEASE; SIZE;
D O I
10.1080/22221751.2021.1888659
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The HIV/AIDS prevalence in female sex workers (FSWs) and elderly male clients is increasing in Guangxi, China, but the transmission relationship between them remains unclear. This study aims to illuminate the transmission network between FSWs and elderly male clients using molecular epidemiological analyses. Phylogenetic analysis indicated that CRF01_AE was the dominant strain, followed by CRF07_BC and CRF08_BC in both groups. Multivariate logistic regression analysis indicated that viral loads of 50 to 1000 copies/mL, immunological treatment failure and CRF07_BC were risk factors for entering the transmission network. Transmission network analysis showed that CRF07_BC tended to form large clusters, whereas CRF01_AE tended to form multiple but small clusters. Two groups of 11 FSWs and 169 clients were intricately intertwined. Spatial analysis demonstrated the formation of hotspots and clusters of transmission sharing regional differences. In conclusion, our study provides direct genetic evidence of transmission linkages between FSWs and elderly male clients. Although the CRF01_AE subtype was still the predominant subtype in the region, the higher degree and larger clusters found in CRF07_BC illustrate a rapid and intensive uptrend, which is expected to increase its prevalence in the region in the future.
引用
收藏
页码:384 / 395
页数:12
相关论文
共 50 条
[41]   Internet Use Among Female Sex Workers in China: Implications for HIV/STI Prevention [J].
Hong, Yan ;
Li, Xiaoming ;
Fang, Xiaoyi ;
Lin, Xiuyun ;
Zhang, Chen .
AIDS AND BEHAVIOR, 2011, 15 (02) :273-282
[42]   HIV/AIDS Among Female Sex Workers in China: Epidemiology and Recent Prevention Strategies [J].
Zhang, Hanxi ;
Hsieh, Evelyn ;
Wang, Lu ;
Liao, Susu .
CURRENT HIV/AIDS REPORTS, 2020, 17 (02) :151-160
[43]   Aphrodisiac Use and Associated Factors Among Older Male Clients of Low-Cost Female Sex Workers in Southwestern Rural Areas of China [J].
Wu, Xinghua ;
Huang, Huiling ;
Tang, Zhenzhu ;
Shen, Zhiyong ;
Lu, Huaxiang ;
Chen, Huanhuan ;
Chen, Li ;
Huang, Hui ;
Ruan, Yuhua ;
Shao, Yiming .
SEXUALITY RESEARCH AND SOCIAL POLICY, 2017, 14 (01) :71-80
[44]   Aphrodisiac Use and Associated Factors Among Older Male Clients of Low-Cost Female Sex Workers in Southwestern Rural Areas of China [J].
Xinghua Wu ;
Huiling Huang ;
Zhenzhu Tang ;
Zhiyong Shen ;
Huaxiang Lu ;
Huanhuan Chen ;
Li Chen ;
Hui Huang ;
Yuhua Ruan ;
Yiming Shao .
Sexuality Research and Social Policy, 2017, 14 :71-80
[45]   Drinking Reasons and Alcohol Problems by Work Venue Among Female Sex Workers in Guangxi, China [J].
Chen, Yiyun ;
Li, Xiaoming ;
Shen, Zhiyong ;
Zhou, Yuejiao ;
Tang, Zhenzhu .
SUBSTANCE USE & MISUSE, 2015, 50 (05) :642-652
[46]   CONDOM USE AMONG FEMALE COMMERCIAL SEX WORKERS AND MALE CLIENTS IN HONG-KONG [J].
WONG, KH ;
LEE, SS ;
LO, YC ;
LO, KK .
INTERNATIONAL JOURNAL OF STD & AIDS, 1994, 5 (04) :287-289
[47]   Genetic characterization of HIV-1 epidemic in Anhui Province, China [J].
Dong Zhang ;
Jianjun Wu ;
Yu Zhang ;
Yuelan Shen ;
Sheying Dai ;
Xiaolin Wang ;
Hui Xing ;
Jin Lin ;
Jingwan Han ;
Jingyun Li ;
Yizu Qin ;
Yongjian Liu ;
Lifeng Miao ;
Bin Su ;
Hanping Li ;
Lin Li .
Virology Journal, 17
[48]   Sexually Transmitted Infections among Heterosexual Male Clients of Female Sex Workers in China: A Systematic Review and Meta-Analysis [J].
McLaughlin, Megan M. ;
Chow, Eric P. F. ;
Wang, Cheng ;
Yang, Li-Gang ;
Yang, Bin ;
Huang, Jennifer Z. ;
Wang, Yanjie ;
Zhang, Lei ;
Tucker, Joseph D. .
PLOS ONE, 2013, 8 (08)
[49]   Distribution of HIV-1 subtypes in female sex workers of Calcutta, India [J].
Mandal, D ;
Jana, S ;
Pahda, S ;
Bhattacharya, S ;
Ghosh, TC ;
Bhattacharya, SK ;
Chakrabarti, S .
INDIAN JOURNAL OF MEDICAL RESEARCH, 2000, 112 :165-172
[50]   Molecular epidemiological tracing of HIV-1 outbreaks in Hainan island of southern China [J].
Deng, Wei ;
Fu, Peng ;
Bao, Linlin ;
Vidal, Nicole ;
He, Qiya ;
Qin, Chuan ;
Peeters, Martine ;
Delaporte, Eric ;
Andrieu, Jean-Marie ;
Lu, Wei .
AIDS, 2009, 23 (08) :977-985