Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction

被引:227
作者
Yang, Yunlong [1 ]
Zhang, Jieyuan [2 ]
Liu, Zhenzhen [1 ]
Lin, Qiuning [1 ]
Liu, Xiaolin [2 ]
Bao, Chunyan [1 ]
Wang, Yang [2 ]
Zhu, Linyong [1 ]
机构
[1] E China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Dept Orthoped Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China
关键词
HYALURONIC-ACID; CHONDROITIN SULFATE; HYDROGELS; BIOMATERIALS; SCAFFOLDS; ADHESIVE; PHOTOENCAPSULATION; CHEMISTRY; CHITOSAN; DESIGN;
D O I
10.1002/adma.201505336
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:2724 / 2730
页数:7
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