Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats

被引：13
作者：
Tanida, Mamoru
Shen, Jiao
Horii, Yuko
Matsuda, Morihiro
Kihara, Shinji
Funahashi, Toru
Shimomura, Iichiro
Sawai, Hajime
Fukuda, Yutaka
Matsuzawa, Yuji
Nagai, Katsuya
机构：
[1] YMP Int Corp, ANBAS Project, Osaka 5310072, Japan
[2] Osaka Univ, Inst Prot Res, Div Prot Metab, Osaka 5650871, Japan
[3] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka 5650871, Japan
[4] Osaka Univ, Grad Sch Med, Dept Physiol & Biosignaling, Osaka 5650871, Japan
来源：
EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 232卷 / 03期
关键词：
adipocytokine; autonomic nervous system; cardiovascular action; hypotensive action; suprachiasmatic nucleus;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Adiponectin is an adipocytokine that modulates energy homeostasis and glucose metabolism. Here, we examined the effects of acute intravenous (iv) and lateral cerebral ventricular (LCV) injections of adiponectin on the renal sympathetic nerve activity (RSNA) and blood pressure (b/p) in urethane-anesthetized rats. Both iv and LCV injections of adiponectin induced dose-dependent suppressions of RSNA and b/p. Moreover, we found that bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of iv injection of adiponectin on RSNA and b/p. These findings suggest that adiponectin decreases the RSNA and b/p in a dose-dependent manner and that the SCN is implicated in mechanism of adiponectin actions on RSNA and b/p. These findings also suggest that the hypotensive-action activity of adiponectin is realized, at least partially, via changes in activities of autonomic nerves activity.
引用
收藏
页码：390 / 397
页数：8
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