Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis

被引：119

作者：

Lamoth, Frederic ^{[1
,2
,3
,4
]}

Chung, Shimin J. ^{[1
,5
]}

Damonti, Lauro ^{[3
]}

Alexander, Barbara D. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Pathol, Clin Microbiol Lab, Durham, NC 27710 USA

[3] Lausanne Univ Hosp, Infect Dis Serv, Dept Med, Lausanne, Switzerland

[4] Lausanne Univ Hosp, Inst Microbiol, Lausanne, Switzerland

[5] Singapore Gen Hosp, Dept Infect Dis, Singapore, Singapore

来源：

CLINICAL INFECTIOUS DISEASES | 2017年 / 64卷 / 11期

关键词：

antifungal prophylaxis; invasive aspergillosis; mucormycosis; Aspergillus ustus; Scopulariopsis; CELL TRANSPLANT RECIPIENTS; MYCOSES STUDY-GROUP; ANTIFUNGAL PROPHYLAXIS; FUNGAL-INFECTIONS; EUROPEAN-ORGANIZATION; SINGLE-CENTER; POSACONAZOLE; DISEASE; FLUCONAZOLE; OUTCOMES;

D O I：

10.1093/cid/cix130

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds.

引用

页码：1619 / 1621

页数：3

共 12 条

[1]

[Anonymous], 2008, REF METH BROTH DIL A

[2] Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: real-life data from a single-centre institutional retrospective observational study [J].

Auberger, Jutta ;

Lass-Floerl, Cornelia ;

Aigner, Maria ;

Clausen, Johannes ;

Gastl, Guenther ;

Nachbaur, David .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (09) :2268-2273

[3] A cohort study on breakthrough invasive fungal infections in high-risk patients receiving antifungal prophylaxis [J].

Biehl, Lena M. ;

Vehreschild, J. Janne ;

Liss, Blasius ;

Franke, Bernd ;

Markiefka, Birgid ;

Persigehl, Thorsten ;

Buecker, Vanessa ;

Wisplinghoff, Hilmar ;

Scheid, Christof ;

Cornely, Oliver A. ;

Vehreschild, Maria J. G. T. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (09) :2634-2641

[4] Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia [J].

Cornely, Oliver A. ;

Maertens, Johan ;

Winston, Drew J. ;

Perfect, John ;

Ullmann, Andrew J. ;

Walsh, Thomas J. ;

Helfgott, David ;

Holowiecki, Jerzy ;

Stockelberg, Dick ;

Goh, Yeow-Tee ;

Petrini, Mario ;

Hardalo, Cathy ;

Suresh, Ramachandran ;

Angulo-Gonzalez, David .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (04) :348-359

[5] Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single-centre study with focus on emerging pathogens [J].

Corzo-Leon, Dora E. ;

Satlin, Michael J. ;

Soave, Rosemary ;

Shore, Tsiporah B. ;

Schuetz, Audrey N. ;

Jacobs, Samantha E. ;

Walsh, Thomas J. .

MYCOSES, 2015, 58 (06) :325-336

[6] Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group [J].

De Pauw, Ben ;

Walsh, Thomas J. ;

Donnelly, J. Peter ;

Stevens, David A. ;

Edwards, John E. ;

Calandra, Thierry ;

Pappas, Peter G. ;

Maertens, Johan ;

Lortholary, Olivier ;

Kauffman, Carol A. ;

Denning, David W. ;

Patterson, Thomas F. ;

Maschmeyer, Georg ;

Bille, Jacques ;

Dismukes, William E. ;

Herbrecht, Raoul ;

Hope, William W. ;

Kibbler, Christopher C. ;

Kullberg, Bart Jan ;

Marr, Kieren A. ;

Munoz, Patricia ;

Odds, Frank C. ;

Perfect, John R. ;

Restrepo, Angela ;

Ruhnke, Markus ;

Segal, Brahm H. ;

Sobel, Jack D. ;

Sorrell, Tania C. ;

Viscoli, Claudio ;

Wingard, John R. ;

Zaoutis, Theoklis ;

Bennett, John E. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (12) :1813-1821

[7] Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species [J].

Iwen, Peter C. ;

Schutte, Stephanie D. ;

Florescu, Diana F. ;

Noel-Hurst, Rhonda K. ;

Sigler, Lynne .

MEDICAL MYCOLOGY, 2012, 50 (06) :561-569

[8] Breakthrough invasive fungal disease in patients receiving posaconazole primary prophylaxis: a 4-year study [J].

Lerolle, N. ;

Raffoux, E. ;

Socie, G. ;

Touratier, S. ;

Sauvageon, H. ;

Porcher, R. ;

Bretagne, S. ;

Bergeron, A. ;

Azoulay, E. ;

Molina, J-M ;

Lafaurie, M. .

CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (11) :O952-O959

[9] Antifungal Prophylaxis in Lung Transplantation-A World-wide Survey [J].

Neoh, C. F. ;

Snell, G. I. ;

Kotsimbos, T. ;

Levvey, B. ;

Morrissey, C. O. ;

Slavin, M. A. ;

Stewart, K. ;

Kong, D. C. M. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 (02) :361-366

[10] Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole or caspofungin prophylaxis [J].

Pavie, J ;

Lacroix, C ;

Hermoso, DG ;

Robin, M ;

Ferry, C ;

Bergeron, A ;

Feuilhade, M ;

Dromer, F ;

Gluckman, E ;

Molina, JM ;

Ribaud, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (09) :4902-4904

← 1 2 →