Recent Advances in Green Synthesis of 3,3′-Spirooxindoles via Isatin-based One-pot Multicomponent Cascade Reactions in Aqueous Medium

被引：85

作者：

Yan, Li-Jun ^{[1
]}

Wang, Yong-Chao ^{[1
]}

机构：

[1] Yunnan Normal Univ, Sch Vocat & Tech Educ, Kunming 650092, Peoples R China

来源：

CHEMISTRYSELECT | 2016年 / 1卷 / 21期

关键词：

3,3 '-spirooxindole; Aqueous medium; Catalyst; Green synthesis; Multicomponent cascade reaction; UREA-SALT MIXTURES; CROSS-COUPLING REACTIONS; STRUCTURE-BASED DESIGN; DIELS-ALDER REACTIONS; CATALYZED ONE-POT; 3-COMPONENT SYNTHESIS; SPIROOXINDOLE DERIVATIVES; ORGANIC-REACTIONS; HETEROGENEOUS CATALYST; REUSABLE NANOCATALYST;

D O I：

10.1002/slct.201601534

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3,3'-spirooxindoles are important synthetic target compounds and play special role in organic chemistry because of their extensive biological activities and applications of pharmaceutical lead discovery. In recent years, there has been a significant increase in design of new, atom economical and eco-friendly isatin-based one-pot multicomponent cascade reactions in aqueous medium for the green synthesis of 3,3'-spirooxindoles. In this review, the recent advances in this area were summarized and classified according to catalyst-free, organiccatalyzed, inorganic-catalyzed, nanometer-silica-catalyzed and enzyme-catalyzed reaction systems. These reviewed methods provide important inspiration for the synthesis of novel 3,3'spirooxindoles and design of new pharmaceutical compounds.

引用

页码：6948 / 6960

页数：13

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