Tyrosine-derived polycarbonate membrane in treating mandibular bone defects.: An experimental study

被引:15
作者
Asikainen, Antti J. [1 ]
Noponen, Jukka
Lindqvist, Christian
Pelto, Mika
Kellomaki, Minna
Juuti, Hanne
Pihlajamaki, Harri
Suuronen, Riitta
机构
[1] Univ Helsinki, Inst Dent, Dept Oral & Maxillofacial Surg, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, Dept Oral & Maxillofacial Surg, Helsinki 00290, Finland
[3] Tampere Univ Technol, Inst Biomat, FIN-33101 Tampere, Finland
[4] Cent Mil Hosp, Res Inst Mil Med, Helsinki 00300, Finland
[5] Univ Tampere, REGEA Inst Regenerat Med, Tampere 33521, Finland
[6] Univ Tampere, Sch Med, Tampere 33521, Finland
[7] Univ Hosp, Tampere 33521, Finland
关键词
poly (desaminotyrosyl-tyrosine-ethyl ester carbonate); bioabsorbable membrane; rabbit; mandible; reconstruction; guided bone regeneration;
D O I
10.1098/rsif.2006.0119
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study was designed to evaluate the suitability of a novel bioabsorbable material in treating bone defects. A poly(desaminotyrosyl-tyrosine-ethyl ester carbonate) (PDTE carbonate) membrane (thickness 0.2-0.3 mm) was implanted into the mandibular angle of 20 New Zealand White rabbits to cover a through-and-through defect (12 x 6 mm). In group 1, the defects were left unfilled but covered with membrane and in group 2 the defects were filled with bioactive glass mesh and covered with membrane, too. Controls were left uncovered and unfilled. The animals were followed for 6, 12, 24 and 52 weeks, respectively. The material was evaluated by qualitative analysis of histological reactions and newly formed bone. We found that PDTE carbonate elicited a modest foreign body reaction in the tissues, which was uniform throughout the study. New bone formation was seen in all samples after six weeks. Group 1 had more new bone formation until 24 weeks and after this the difference settled. Based on findings of this study it was concluded that PDTE carbonate membranes have good biocompatibility and are sufficient to enhance bone growth without additional supportive matrix.
引用
收藏
页码:629 / 635
页数:7
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