Benzosceptrins A and B with a Unique Benzocyclobutane Skeleton and Nagelamide S and T from Pacific Sponges

被引：44

作者：

Appenzeller, Jerome ^{[1
]}

Tilvi, Supriya ^{[1
]}

Martin, Marie-Therese ^{[1
]}

Gallard, Jean-Francois ^{[1
]}

El-bitar, Hoda ^{[1
]}

Dau, Elise Tran Huu ^{[1
]}

Debitus, Cecile ^{[2
]}

Laurent, Dominique ^{[3
]}

Moriou, Celine ^{[1
]}

Al-Mourabit, Ali ^{[1
]}

机构：

[1] CNRS, UPR 2301, Inst Chim Subst Nat, Ctr Rech Gif Sur Yvette, Ave Terrasse, F-91198 Gif Sur Yvette, France

[2] Ctr Polynesien Rech Biodiversite Insulaire, IRD UMR 152, Papeete, France

[3] Univ Toulouse 3, UMR IRD 152, F-31062 Toulouse 9, France

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 21期

关键词：

DIMERIC BROMOPYRROLE ALKALOIDS; AGELAS; 2-AMINOIMIDAZOLE; PROLINE; OROIDIN;

D O I：

10.1021/ol901946h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new dimeric pyrrole-2-aminoimidazole alkaloids have been isolated from the Pacific marine sponges Agelas cf. mauritiana and Phakellia sp. They include the unusual C2 symmetrical benzosceptrins A (4) and B (5), which each possess a unique benzocyclobutane skeleton and nagelamides S (6) and T (7). Their structures and relative configuration were elucidated from spectroscopic data. Plausible biogenetic paths for these compounds are also proposed in this paper.

引用

页码：4874 / 4877

页数：4

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