Role of connexin 26 (GJB2) & mitochondrial small ribosomal RNA (mt 12S rRNA) genes in sporadic & aminoglycoside-induced non syndromic hearing impairment

被引：0
作者：
Lingala, Hema Bindu [1 ,2 ]
Sankarathi [3 ]
Penagaluru, Pardhanandana Reddy [1 ,2 ]
机构：
[1] Osmania Univ, Dept Environm Toxicol, Inst Genet, Hyderabad 500016, Andhra Pradesh, India
[2] Osmania Univ, Hosp Genet Dis, Hyderabad 500016, Andhra Pradesh, India
[3] Univ Madras, Dr ALM PGIBMS, Madras, Tamil Nadu, India
来源：
INDIAN JOURNAL OF MEDICAL RESEARCH | 2009年 / 130卷 / 04期
关键词：
Aminoglycosides; connexins; heterozygosity; homoplasmic; matrilineal; PRELINGUAL DEAFNESS; RECESSIVE DEAFNESS; SENSORINEURAL DEAFNESS; MOLECULAR-BASIS; HIGH-FREQUENCY; GAP-JUNCTION; CHILDHOOD DEAFNESS; INHERITED DEAFNESS; PEDIATRIC SUBJECTS; A1555G MUTATION;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Non syndromic hearing impairment is a common sensory disorder, which affects one in 600 newborns. Though more than 50 nuclear genes are involved in causing non syndromic hearing impairment, mutations in the connexin 26 (GJB2) gene explain a high proportion of congenital deafness in several populations worldwide. The diversity, of genes and genetic loci implicated in hearing loss defines the complexity of the genetic basis of hearing. This review focuses on the role of connexin 26 and mitochondrial 12S rRNA genes in hearing which will be helpful for better understanding of genes in sporadic and aminoglycoside-induced non syndromic hearing impairment.
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页码：369 / 378
页数：10
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