Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders

被引：58

作者：

Harrell, Carl Randall ^{[1
]}

Volarevic, Ana ^{[2
]}

Djonov, Valentin ^{[3
]}

Volarevic, Vladislav ^{[4
]}

机构：

[1] Regenerat Proc Plant LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684 USA

[2] Univ Kragujevac, Dept Cognit Psychol, Ctr Mol Med & Stem Cell Res, Fac Med Sci, 69 Svetozar Markovic St, Kragujevac 34000, Serbia

[3] Univ Bern, Inst Anat, Baltzerstr 2, CH-3012 Bern, Switzerland

[4] Univ Kragujevac, Dept Microbiol & Immunol, Ctr Mol Med & Stem Cell Res, Fac Med Sci, 69 Svetozar Markovic St, Kragujevac 34000, Serbia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

mesenchymal stem cells; exosomes; neurocognitive disorders; REGULATING INFLAMMATORY RESPONSES; EXTRACELLULAR VESICLES; STROMAL CELLS; FUNCTIONAL RECOVERY; PARKINSONS-DISEASE; RESCUE; NEUROGENESIS; DYSFUNCTION; IMPAIRMENT; MODEL;

D O I：

10.3390/ijms22031433

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.

引用

页码：1 / 13

页数：13

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